ArticleTo drink or not to drink: Tests of anxiety and immobility in alcohol-preferring and alcohol-nonpreferring rat strains
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2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :In line with the above, sP rats showed less central activity than sNP rats in the open field test (Roman et al., 2012). In contrast, alcohol-naïve P rats were more active, i.e. spent less time immobile, in the forced swim test and scored more entries into the open arms of the elevated plus maze as compared to their NP counterparts (Godfrey et al., 1997; Viglinskaya et al., 1995; but see also—Stewart et al., 1993). Hence, the P line of rats may be considered an animal model of some subtypes of alcoholism associated with high novelty seeking and low harm avoidance.
Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :In agreement with the current observations, ethanol-naïve sP rats spent less time and made fewer entries into the open arms of EPM than ethanol-naïve sNP rats suggesting a higher innate level of anxiety in sP than in sNP rats (Casu et al., 2004; Colombo et al., 1995; Leggio et al., 2003; Richter et al., 2000). In contrast, no difference between the strains (AA vs. ANA and HAD vs. LAD) in the time spent into open arms of the EPM was observed (Badia-Elder et al., 2003; Hwang et al., 2004; Viglinskaya et al., 1995). In the current study, we hypothesize that increased anxiety-related behavior may predict increased voluntary alcohol intake during continuous access and that higher anxiety level is predisposing risk factor for alcohol drinking in mice.