ArticleFood intake and serum insulin responses to intraventricular infusions of insulin and IGF-I
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2020, Neurobiology of DiseaseCitation Excerpt :In such studies, the IGF-1 receptor and perhaps other receptors as well could be activated (Rechler and Nissley, 1986). CNS insulin infusion decreases serum insulin levels, which appears to be independent of a change in food intake (Foster et al., 1991). Less studied is the role of insulin receptor signaling in other cell types of the neurovascular unit (astrocytes, pericytes, brain endothelial cells) and how this signaling might affect the BBB (Rhea and Banks, 2019).
Central and peripheral administrations of insulin-like growth factor-1 suppress food intake in chicks
2017, Physiology and BehaviorCitation Excerpt :In mammals, the effects of central administration of IGF-1 on food intake are controversial. Intracerebroventricular administration of IGF-1 did not influence food intake in sheep [10] but significantly increased food intake in rats [34]. However, intracerebroventricular administration of IGF-1 significantly decreased food intake in diabetic rats [21].