Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Radiation induction of micronuclei in human lymphocytes
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Cited by (154)
Dependence of micronuclei assay on the depth of absorbed dose
2017, Reports of Practical Oncology and RadiotherapyCitation Excerpt :As illustrated in Fig. 1(a), the obtained dose–response curves, obtained at all depths, showed the best fitness with the linear–quadratic models. The variations of the micronuclei response as a function of absorbed dose through a quadratic equation are comparable with the studies of Prosser et al.35 and Silva et al.36 Likewise, they obtained a quadratic equation for the dose–response curve in the micronuclei method. As displayed in Fig. 1(a), for doses up to 2 Gy the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm.
Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation
2016, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :Gender-related differences in MN frequency could not be evaluated, since only male individuals were analyzed. Several studies have reported the CBMN assay to be a sensitive method for detection of radiation-induced genomic damage [45–54]. Our results indicated no statistically significant difference in the frequencies of MN between individuals from HLNRA and NLNRA.
Dicentric chromosome aberration analysis using giemsa and centromere specific fluorescence in-situ hybridization for biological dosimetry: An inter- and intra-laboratory comparison in Indian laboratories
2014, Applied Radiation and IsotopesCitation Excerpt :Quantification of the absorbed radiation dose by measuring dicentric chromosomes (DC) from peripheral blood lymphocytes of exposed individuals is the gold standard and is recommended for all biodosimetry laboratories (Bender et al., 1988). While biodosimetry based cytogenetic assays like the cytokinesis-blocked micronucleus (CBMN) technique (Prosser et al., 1988), fluorescence in-situ hybridization (FISH) (Pinkel et al., 1986), and premature chromosome condensation (PCC) (International Atomic Energy Agency, 1986) have advantages as well as limitations. Measurement of DC is both specific and sensitive to the absorbed radiation dose.
Cytogenetic effects of recombinant interferon-γ on lymphocytes cultures from patients with non-small cell lung cancer
2009, Cancer Genetics and CytogeneticsCitation Excerpt :The effect of radiation (x-rays) on the frequency of SCE is less than the effect on the chromosome abnormalities. Some authors state that radiation-induced SCE may be false, and that they result from chromosomal aberrations induced in G0 or G1, such as translocations, insertions, and inversions [23–27]. In our study, no statistically significant effect of radiotherapy was found on SCE frequencies 30 days after radiotherapy, and that was expected since there was enough time for repair mechanisms.
Review of relative biological effectiveness dependence on linear energy transfer for low-LET radiations
2009, Journal of Radiological ProtectionDevelopment of a micronucleus test using the EpiAirway™ organotypic human airway model
2023, Genes and Environment