Effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole on DNA synthesis of cultured human fibroblasts
References (22)
- et al.
Biochim. Biophys. Acta
(1992) Anal Biochem.
(1976)- et al.
Anal. Biochem.
(1985) - et al.
Anal. Biochem.
(1987) - et al.
Anal. Biochem.
(1987) - et al.
J. Chromatogr.
(1989) Anal. Biochem.
(1990)- et al.
FEBS Lett.
(1989) - et al.
Biochem. Biophys. Res. Commun.
(1988) - et al.
Adv. Metab. Disord.
(1975)
Nature
Cited by (41)
Ultrasensitive determination of pyrroloquinoline quinone in human plasma by HPLC with chemiluminescence detection using the redox cycle of quinone
2017, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Pyrroloquinoline quinone (PQQ, 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid) is a cofactor for methanol dehydrogenase [1] and is categorized as a member of the vitamin B family [2]. PQQ plays important roles in mammals, including protection against liver [3], heart [4], and brain injuries [5], enhancement of the synthesis of DNA in human fibroblasts [6], and promotion of the production of the nerve growth factor [7]. In addition, it has a defensive effect against embryonic cataract induced by hydrocortisone [8] and acts as a radical scavenger [9,10].
Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells
2015, International Journal of Developmental NeuroscienceCitation Excerpt :PQQ may stimulate epithelial cell proliferation by activating epidermal growth factor receptor by oxidation and subsequent inactivation of protein tyrosine phosphatase 1B via its redox cycling (Kimura et al., 2012). In cultured fibroblasts, PQQ also acts as a potential growth factor to enhance cell proliferation when added to cell cultures (Naito et al., 1993; Kumazawa et al., 2007). The most promising application of PQQ has potentially been in neuroprotection, which could be implicated either the functioning of PQQ as a redox sensor to oxidative stress or as a signaling molecule helping in the growth of neurons (Misra et al., 2012).
Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice
2014, Behavioural Brain ResearchCitation Excerpt :Recently, PQQ has received attention for its ability to inhibit amyloid fibril formation [58] and protect the brain against oxidative damage [59,60]. Moreover, in human fibroblast cultures, PQQ and its derivative imidazolopyrroloquinoline enhance cell growth and proliferation when added to cultures at nmol/L concentrations [61]. In the brain, NMDA receptors are considered to be among the most critical molecular regulators of cognition, memory, motor control, and synaptic plasticity [62].
Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling
2012, Free Radical Biology and MedicineCitation Excerpt :ANOVA followed by Dunnett's t tests was performed on sample means. To examine whether PQQ enhances proliferation of epithelial cells, as observed in fibroblasts [19,20], we exposed cultured cells of a human epithelial cell line, A431 cells, to PQQ for 72 h in serum-free medium. Cell growth was determined from the reduction of WST-8 by cellular dehydrogenases present in viable cells, and the Click-iT EdU assay based on DNA synthesis.
Effect of pyrroloquinoline quinone (PQQ) on melanogenic protein expression in murine B16 melanoma
2009, Journal of Dermatological ScienceCitation Excerpt :Kumazawa et al. [7] reported that various foods and vegetables contained PQQ. Naito et al. [8] showed that PQQ could stimulate DNA synthesis in cultured human fibroblasts. A recent study indicated that PQQ-deficient mice had a low amount of mitochondria in their livers and elevated levels of plasma glucose concentrations [9].