The effect of 6-chlorotryptophan on sleep in the rat

doi:10.1016/0024-3205(72)90041-0

Life Sciences

Volume 11, Issue 19, Part 1, 1 October 1972, Pages 893-903

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Abstract

The intraperitoneal injection of 6-CT, a highly specific inhibitor of tryptophan hydroxylase, induced a short lasting period of reduced PS and SWS. This sleep decrease was followed by a progressive rebound in both PS and SWS, which reached a maximum 12 hours after the injection. DL-5-HTP injection after 6-CT administration did not affect the initial sleep decrease observed, but the PS “rebound” was no longer observed. These results differ from those observed after inhibition of tryptophan hydroxylase by parachlorophenylalanine.

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The effect of p-bromomethamphetamine (V-111) on sleep in the rat
1981, European Journal of Pharmacology
p-Bromomethamphetamine (V-111) was given as a single dose to one group of rats and for 28 days to another group and its influence was studied on the sleep-waking cycle. In a third group of rats the midbrain raphe nuclei was lesioned before administration of the drug. A single dose of 15 mg/kg s.c. V-111 produced total insomnia, the SWS returned 15–16 h, REM sleep 21–22 h after the injection. When the drug was given repeatedly the periods of insomnia were gradually shortened. At the end of the third week the SWS returned in daytime after 3 h, at night after 6 h, REM sleep after 6 h and 8 h respectively. The destruction of the midbrain raphe nuclei failed to influence either the spontaneous sleep patterns or the insomnia elicited by V-111. In physiological conditions the integrity of 5-HT system is necessary for the regulation of sleep-waking cycle. After reduction of brain 5-HT, insomnia developed but the sleep-waking cycle could be restored while the brain 5-HT was decreased. The restored sleep mechanisms seem to be 5-HT dependent also.
Preparation of Optically Active 6-Chlorotryptophan and Tryptophan
1975, Journal of Agricultural and Food Chemistry

^☆: This work has been supported by D.R.M.E. (Grant 71-009).

¹: We wish to thank Pr. PACHECO (Institut National des Sciences Appliquées, 69 Villeurbanne, France) for synthetizing and graciously providing the 6-chlorotryptophan.

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The effect of 6-chlorotryptophan on sleep in the rat☆

Abstract

Life Sci.

Pharmacol. Res. Commun.

Brain Res.

Eur. J. Pharmacol.

Brain Res.

Electroenceph. clin. Neurophysiol.

C. R. Soc. Biol.

J. Neurochem.

Mol. Pharmacol.