Selective D2 dopamine receptor agonists prevent catalepsy induced by SCH 23390, a selective D1 antagonist
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The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal
2022, NeuroscienceCitation Excerpt :Importantly, we do not mean to claim that SCH did not induce any kind of motor impairment in our rats. The periods of freezing in the receptacle that we observed after SCH administration are more likely to represent catalepsy than sleep, in agreement with other reports of SCH-induced catalepsy (Meller et al., 1985; Morelli and Di Chiara, 1985). However, the degree of catalepsy induced by the dose of SCH used in this study was small enough to allow animals to respond efficiently to cues when their level of arousal was high, which might be at least in part due to the alleviation of SCH-induced catalepsy by arousal.
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