Signal to noise and spatial localization of NMR spectra with a surface coil and the saturation-recovery sequence

https://doi.org/10.1016/0022-2364(85)90182-9Get rights and content

Abstract

Surface coils are widely used to study in vivo biochemistry by NMR spectroscopy. For inhomogeneous samples, the coil geometry and pulse sequence parameters have to be chosen by taking into account both signal-to-noise ratio and spatial localization of the signal. For the usual single-pulse sequences the position of maximum sensitivity and the spatial selectivity are dependent upon the spin-lattice relaxation time T1. This is source of difficulty with samples containing biochemical species with different relaxation times. It can be palliated by using a long repetition time Tr ⪸ 2-̊3T1 but at the cost of degraded signal-to-noise ratio. The use of the saturation-recovery method provides the same spatial selectivity as a single-pulse sequence with Tr ⪸ 2−3T1 but with better sensitivity. Furthermore the position of the maximum sensitivity surface is not dependent on the spin-lattice relaxation time. The saturation-recovery method can also be used to improve sensitivity with depth pulses, spin-echo techniques, or rotating-frame imaging.

References (20)

  • J.L Evelhoch et al.

    J. Magn. Reson.

    (1984)
  • A Haase et al.

    J. Magn. Reson.

    (1984)
  • M.R Bendall

    Chem. Phys. Lett.

    (1983)
  • A Haase et al.

    J. Magn. Reson.

    (1983)
  • D.I Hoult et al.

    J. Magn. Reson.

    (1976)
  • A Haase et al.

    Lancet

    (1983)
  • M Rance et al.

    J. Magn. Reson.

    (1983)
  • M Decorps et al.

    FEBS Lett.

    (1984)
  • J.J.H Ackerman et al.

    J. Magn. Reson.

    (1984)
  • R Gonzalez-Mendez et al.

    J. Magn. Reson.

    (1984)
There are more references available in the full text version of this article.

Cited by (28)

  • Rapid Rotating-Frame Imaging Using an RF Pulse Train (RIPT)

    1994, Journal of Magnetic Resonance, Series B
View all citing articles on Scopus
View full text