Journal of Chronic Diseases
Biologic variation of human serum immunoglobulin concentrations: Sex-age specific effects☆
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A differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by glatiramer acetate in relapsing-remitting multiple sclerosis patients
2019, Multiple Sclerosis and Related DisordersCitation Excerpt :Based on this, our results suggest a shift in the production of subclasses of IgG anti-GA with an increase in IgG4 and IgG3 and a decrease in IgG1 due to GA treatment in patients with RR-MS. Knowledge of the influence of sex in antibody production and IgG subclasses is scattered and still limited (Butterworth et al., 1967; Cassidy et al., 1974; Ward et al., 1991). However, our results suggest a sex-dependent production of subclasses of IgG2 and IgG4 anti-GA antibodies, with higher levels of these subclasses in males than in females.
IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia
2019, Blood AdvancesCitation Excerpt :In contrast, IgM reduction occurred at equal frequency in all patients. The reason for this is unclear, but it is unlikely to be related to aging, because IgM levels remain stable throughout life, whereas IgG and IgA levels actually increase with age.35,36 Elevated immunoglobulin levels were observed in about 5% of patients, with the incidence depending on tumor burden, being most frequent in patients with advanced Rai stage CLL.
Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In the WBCA, when IL-8 was induced at 100 μg/mL in the non-responders, CD28SA binding to monocytes or granulocytes was observed at 100 μg/mL, whereas in the responder IL-8 was induced at ≥1 μg/mL (Fig. 2A). Serum-derived IgG in the WBCA is estimated at 10 mg/mL, based on the normal blood IgG level [17]. Such a high treatment concentration as 100 μg/mL of CD28SA might be needed to bind FcγRs in the assay condition in this study because IgG4, the subclass of CD28SA, has weaker binding affinity to FcγRs than IgG1, the most predominant IgG subclass in blood [18].
Host and Environmental Factors Influencing Individual Human Cytokine Responses
2016, CellCitation Excerpt :IgA has been implicated with several age-related diseases such as macular degeneration and diabetes, which makes IgA a potential therapeutic agent for prophylaxis and/or treatment (Rodriguez-Segade et al., 1996; Yu et al., 2016). Higher IgA was also detected in men compared to women, as supported by earlier studies, while circulating concentrations of IgM were higher in women (Cassidy et al., 1974; Obiandu et al., 2013; Weber-Mzell et al., 2004). In another study from the HFGP (Aguirre-Gamboa et al., 2016), IgG2 and IgG4 are shown to significantly interact with age and gender, respectively.
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This work was supported by grants from the Institute of Gerontology of The University of Michigan and Wayne State University, The University of Michigan Medical School Fund for Computing, and the Michigan Chapter of The Arthritis Foundation. The Rackham Arthritis Research Unit is supported in part by a grant from the Horace H. Rackham School of Graduate Studies. The Tecumseh Communith Health Study is supported by Program Project Grant HL 09814 from The National Heart and Lung Institute, National Institutes of Health.