Research reportInhibitory effect of a single local probucol administration on neointimal formation in balloon-injured rat carotid artery
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Elsibucol inhibits atherosclerosis following arterial injury: Multifunctional effects on cholesterol levels, oxidative stress and inflammation
2014, AtherosclerosisCitation Excerpt :Probucol is a cholesterol-lowering drug with antioxidant and anti-inflammatory properties [8]. It has been shown to inhibit neointimal formation after balloon injury in swine coronary [9] and in rat and rabbit carotid arteries [10,11]. In humans, probucol can stop the progression of atherosclerotic plaques in carotid arteries [12] and inhibit restenosis in coronary arteries [13].
Prevention of neointima formation by taurine ingestion after carotid balloon injury
2010, Vascular PharmacologyCitation Excerpt :Proliferating smooth muscle cells, myocytes and fibroblasts (Szöcs et al., 2002), as well as the infiltrating macrophages and neutrophils (Okamoto et al., 2001) produce ROS in the vessel wall (Szöcs et al., 2002). Indeed, pharmacological antioxidant intervention with probucol (Ishizaka et al., 1995) or N-acetylcysteine (Mass et al., 1995) has been shown to reduce neointima formation. Taurine, a sulfur-containing amino acid, is abundantly present in animal tissues and plays roles in several essential biological processes (Huxtable, 1992).
Experimental Therapies of the Vessel Wall
2009, Clinical Lipidology: A Companion to Braunwald's Heart DiseaseExperimental Therapies of the Vessel Wall
2008, Clinical Lipidology: A Companion to Braunwald's Heart Disease Expert Consult: Online and PrintClinical results with AGI-1067: A novel antioxidant vascular protectant
2003, American Journal of CardiologyCitation Excerpt :Indeed, coated stents cannot alter the diffuse progression of the atherosclerotic process and the clinical events related to it. It is nevertheless conceivable that a stent coated with an antioxidant may be developed in the future because local62 and systemic therapy with antioxidants/v-protectants may be complementary for the prevention of restenosis and atherosclerosis progression. The results of large, prospective epidemiologic studies have supported a protective role for antioxidant vitamins in cardiovascular diseases.63
Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits
2001, Free Radical Biology and MedicineCitation Excerpt :Ferns and colleagues [14] found that dietary probucol resulted in a 51% decrease in the intima/media ratio 5 weeks after carotid arterial injury. This effect of probucol has also been observed by others in the rabbit aorta [38], rat carotid artery [39], and porcine coronary arteries [16]. Similar observations have been observed with other antioxidant treatments.