Effects of the nonsteroidal aromatase inhibitor, Fadrozole, on sexual behavior in male rats
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Cited by (72)
The effect of letrozole administration on the aggressive behavior and reproductive parameters of male goats (Capra hircus)
2019, Small Ruminant ResearchCitation Excerpt :A large number of chemicals including some phytoestrogens, xenoestrogens, fungicides, and organotins have been reported to inhibit aromatase activity in in vitro assays (Sanderson, 2006; Cheshenko et al., 2008). However, the in vivo activity of these compounds on aromatase inhibition is not well characterized The inhibition of this enzyme’s activity by xenobiotic exposure or aromatase inhibitors has been shown to adversely affect gonad function (male rats; Gerardin and Pereira, 2009), development (rats; Cappon et al., 2011, Medaka; Thresher et al., 2001) and behaviour (Japanese quail; Bonsall et al., 1992; Corni et al., 2006). Information about the possible impact of exposure to environmental estrogenic compounds on animal and human reproductive health, together with the realization that abnormal P450-aromatase expression can result in disease (Fowler et al., 2000), pointed to the importance of studying the role of estrogens on male reproductive health (Toppari et al., 1996; Lombardi et al., 2001).
Male Sexual Behavior
2017, Hormones, Brain and Behavior: Third EditionTwo aromatase inhibitors inhibit the ability of a third to promote mating in male rats
2015, Hormones and BehaviorCitation Excerpt :But aromatase is also found in tissues where the estrogen produced acts locally, such as breast and the preoptic area (POA) of the brain. The POA is a site where T acts to stimulate male sex behavior, particularly mounting, and E formed there mediates at least some effects of T. Like T, E promotes mounting, and this effect of T, but not E, is blocked by ATD and fadrozole in male monkeys, rats and quail (Morali et al., 1977; Adkins et al., 1980; Bonsall et al., 1992; Zumpe et al., 1993; Foidart et al., 1995; Vagell and McGinnis, 1997). The only 6α-halogenated androgen studied in regard to mating, 6α-fluoroT, was studied, before it was known to inhibit aromatase, because it is nonaromatizable (Gual et al., 1962) yet has the same A-ring as T; thus, it dissociates features commonly confounded in nonaromatizable androgens like 5α-dihydroT (DHT; Thompson and Siiteri, 1974) that do not support mating.
Sexual responses of the male rat medial preoptic area and medial amygdala to estrogen I: Site specific suppression of estrogen receptor alpha
2012, Hormones and BehaviorCitation Excerpt :Mating was significantly reduced in male rats when the conversion of T to E2 was blocked by the administration of Fadrozole, a non-steroidal aromatase inhibitor (Lipton et al., 1990; Vagell and McGinnis, 1997), either systemically (Bonsall et al., 1992) or locally into the medial preoptic area (MPO) (Clancy et al., 1995) or into the medial amygdala (MEA) (Huddleston et al., 2006). Such behavioral deficits are partially reversed by systemic E2 administration (Bonsall et al., 1992) or local E2 implants into either the MPO (Clancy et al., 2000) or the MEA (Huddleston et al., 2003), brain areas where mating-induced Fos-immunoreactivity (‐ir) is colocalized in neurons expressing either androgen receptors, estrogen receptors (ER) or both androgen receptors and ER (Gréco et al., 1998). Although the MPO and MEA express both the alpha (ERα) and beta (ERβ) subtypes of ER, the mechanism by which E2 acts in these areas is not known (Gréco et al., 2003; Shughrue and Merchanthaler, 2001).