Bendazac prevents cyanate binding to soluble lens proteins and cyanate-induced phase-separation opacities in vitro: a possible mechanism by which bendazac could delay cataract
References (14)
- et al.
Aspirin prevents carbamylation of soluble lens proteins and prevents cyanate-induced phase-separation opacities in vitro: a possible mechanism by which aspirin could prevent cataract
Exp. Eye Res.
(1985) - et al.
The lens: development, proteins, metabolism and cataract
- et al.
Carbamylation of lens proteins: a possible factor in cataractogenesis in some countries
Exp. Eye Res.
(1980) - et al.
Dehydrational crises from severe diarrhoea or heatstroke and risk of cataract
Lancet
(1984) - et al.
Effects of bendazac l-lysine salt on X-ray-induced cataract in the rabbit lens
Exp. Eye Res.
(1986) - et al.
Pilot study of bendazac for treatment of cataract
Lancet
(1982) - et al.
Conformational changes induced in bovine lens alpha-crystallin by carbamylation. Relevance to cataract
Biochem. J.
(1984)
Cited by (23)
Avenues for post-translational protein modification prevention and therapy
2022, Molecular Aspects of MedicineCitation Excerpt :Eicosapentaenoic acid supplementation in mice decreased mitochondrial protein carbamylation (Johnson et al., 2015), and triclosan similarly inhibited carbamylation (Bright et al., 2018). Aspirin, ibuprofen, and bendazac have all been shown to inhibit carbamylation events that commonly pathologically occur on lens proteins (Crompton et al., 1985; Lewis et al., 1986; Plater et al., 1997; Rao and Cotlier, 1988). Again, these studies are either in vitro or animal studies, and have not been translated to clinical applications and serve as areas for future investigation.
Protein Carbamylation in Chronic Kidney Disease and Dialysis
2018, Advances in Clinical ChemistrySynthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents
2010, Bioorganic and Medicinal Chemistry LettersCarbamylated LDL
2010, Advances in Clinical ChemistryCitation Excerpt :However, ibuprofen has no acetyl group, and a different mechanism may apply. Bendazac also inhibits the carbamylation of lens protein when present with cyanate [180]. The targeting of the uptake via scavenger receptors seems to be more achievable and clinically used statins and PPAR gamma ligands were shown to be partially effective in mice to control scavenger receptor expression and functionality [181, 182].
Antidenaturant drugs for cataract and other condensation diseases
2001, Medical HypothesesSpectroscopic characterization of bendazac and benzydamine: Possible photochemical modes of action
1996, Biochemical and Biophysical Research Communications