The antigenic structure of chick β-crystallin subunits

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Abstract

Chick β-crystallins are a family of heteropolymers which, although of a range of sizes and electrophoretic mobilities, are antigenically related to each other, in part by containing subunits in common with other members of the series. The total number of subunits is probably about 12–14 and these are immunologically distinct, no two having the same complement of antigenic determinants. Of 14 separated polypeptide chains, 12 are shown to be antigenically related by the overlapping distribution of determinants. Of 14 determinants identified on these 12 subunits, six were found on several of them. A further two determinants were found on two other subunits which are not apparently antigenically related to the remainder. It is suggested that the β-crystallins have evolved as a result of gene duplication and divergence.

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