Fucoidin inhibits attachment of guinea pig spermatozoa to the zona pellucida through binding to the inner acrosomal membrane and equatorial domains☆
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Defending the Zygote: Search for the Ancestral Animal Block to Polyspermy
2005, Current Topics in Developmental BiologyCitation Excerpt :Similarly, in vitro insemination with a wide range of serine protease inhibitors never completely inhibits eutherian fertilization (Takano et al., 1993), and acrosin‐null sperm are still able to fertilize eggs, albeit with a 30‐min delay in sperm penetration compared to heterozygous or wild type genotypes (Adham et al., 1997; Baba et al., 1994; Honda et al., 2002; Nayernia et al., 2002). The retention of acrosin on the surface of acrosome‐reacted sperm, particularly at domains most available for ECM binding, suggests an alternative role for acrosin as a tether that maintains sperm–egg interactions (Castellani‐Ceresa et al., 1983; Howes et al., 2001; Huang and Yanagimachi, 1984; Jones, 1991; Noguchi and Nakano, 1992; Sawada, 2002; Urch and Patel, 1991). Acrosin could also be involved with the dispersal and/or activation of acrosome proteins (Honda et al., 2002; Takano et al., 1993; Yamagata et al., 1998b) because the presence of endogenous levels of activity during fertilization is consistently associated with a selective advantage over sperm with low levels of activity, as observed in mice (Adham et al., 1997; Yamagata et al., 1998a) and humans (Cui et al., 2000; Shimizu et al., 1997).
Fertilization and development initiation in orthodox and unorthodox ways: From normal fertilization to cloning
2003, Advances in BiophysicsThe glycobiology of gametes and fertilisation
1999, Biochimica et Biophysica Acta - General SubjectsFucoidin binding activity and its localization on human spermatozoa
1993, ContraceptionThe role of carbohydrate recognition during human sperm-egg binding
2013, Human Reproduction
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This work was supported by USPHS grants HD-03402 and HD05944-03.