Restoration of endothelium-dependent relaxation in both hypercholesterolemia and diabetes by chronic taurine
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Cited by (57)
Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids
2020, Nitric Oxide - Biology and ChemistryCitation Excerpt :Indeed, taurine has been shown exert antioxidative effect in endothelial cells [16,17] and inhibit angiotensin II action in cardiomyocytes [16,17]. In addition, intake of diets supplemented with taurine or with taurine-conjugated BAs showed a hypotensive effect in both rats and humans [18–24], attenuating the endothelial dysfunction associated with hypertension, diabetes, and hypercholesterolemia [21,22,24–29]. This hypotensive effect is quite significant, as studies with different experimental hypertensive rats showed that taurine supplementation reduced blood pressure (BP) by ≈ 11–49 mmHg [18,20,22] while taurine-conjugated BAs by ≈ 24–61 mmHg [23,24].
Prophylactic role of taurine and its derivatives against diabetes mellitus and its related complications
2017, Food and Chemical ToxicologyCitation Excerpt :Taurine reverses the atherosclerosis associated decrease in high density lipoprotein (HDL) cholesterol in the plasma (Mochizuki et al., 1998). Chronic administration of taurine normalizes endothelium dependant cellular activities in diabetic patients (Kamata et al., 1996; Kim et al., 2007). Endothelial dysfunction is characterized by arterial stiffness.
Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats
2017, Biomedicine and PharmacotherapyCitation Excerpt :It plays a crucial role in a metabolic activity such as detoxification, membrane stability, bile acid conjugation, regulation of cellular calcium levels, and osmoregulation. Also, it has been used in many treatments of disease such as cystic fibrosis, hypercholesterolemia, epilepsy, Alzheimer, cardiovascular and hepatic disorders [9–11]. Moreover, some researchers suggest that taurine has a protective effect on oxidative stress caused by chemicals such as cyclosporine A [12], arsenic [13], and ethanol [14] in rats.
Nutrition and Atherosclerosis
2015, Archives of Medical ResearchCitation Excerpt :Taurine uptake into the cells is mediated by a taurine transport system (46). Taurine is believed to have cardiovascular protective effects by the following five possible mechanisms: a) attenuation of vascular contractility by the activation of the potassium channels KIR, KATP and KCa (47) in several animal models like streptozotocin-induced diabetic mice (48) and rats (49); b) decrease of serum VLDL-C and LDL-C levels by improving LDLr binding capacity (50), reduction of apolipoprotein B-100 and VLDL secretion in HepG2 cells (51) and from the liver in rats (52,53) and mice (54) animal models, and activation of the bioconversion of cholesterol to bile acid via upregulation of cholesterol 7 alpha-hydroxylase expression (55); c) protection of vascular endothelial cells from apoptosis under hypertonic stress (56); d) reduction of ox-LDLs by decreasing the expression of oxidized LDL receptor-1 and soluble ICAM-1 (57); and e) reduction of the number of leukocytes and the migration of leukocytes to the vascular endothelium (58). Olive oil is the principal component of MeD.
Effects of taurine on the reactivity of aortas from diabetic rats
2008, Life Sciences