Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems
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Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test
2022, Biomedicine and PharmacotherapyCitation Excerpt :Intraperitoneal injection of acetaminophen has been reported to induce a significant increase in 5-hydroxytryptamine (5-HT) concentration in the pontine and cortical areas [17]. The analgesic effect of acetaminophen is reported to be mediated, at least in part, by the activation of the spinal 5-HT receptor [14-16,2,23,3,5,7]. These data suggest that the analgesic effect of acetaminophen may involve the spinal 5-HT system.
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Copyright © 1991 Published by Elsevier B.V.