Inhibition of murine embryonic development by α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase
References (39)
- et al.
The synthesis and accumulation of polyamines in reproductive organs of the rat during pregnancy
Biochim. Biophys. Acta
(1976) - et al.
Polyamines in rapid growth and cancer
Biochim. Biophys. Acta
(1978) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Polyamine biosynthesis and accumulation during the early development of the Nudibranch Phestilla Sibogae
Devl. Biol.
(1977) Regulation of polyamine biosynthesis
Biochem. Pharmacol.
(1979)- et al.
Biosynthesis and metabolism of putrescine in the rat placenta
Biochem. Pharmacol.
(1977) - et al.
Polyamines in the developing rat and in supportive tissues
Biochim. Biophys. Acta
(1972) - et al.
A method for sequential quantitative separation and determination of protein, RNA, DNA, lipid and glycogen from a single rat liver homogenate or from a subcellular fraction
Anal. Biochem.
(1967) - et al.
New aspects of polyamine biosynthesis in eukaryotic organisms
Effects de deux inhibiteurs de la biosynthèse des polyamines sur la différenciation primaire de l'oeuf de souris
Compt. Rend. Ser. D.
(1978)
Definition of period of induction of deciduoma in the rat using ornithine decarboxylase as a marker of growth onset
Int. J. Fertil.
Inhibition of induction of deciduoma by acute administration of antibody to progesterone
Life Sci.
Substrate-induced irreversible inhibition of α-aminoacid decarboxylases. Application to glutamate, aromatic-L-α-aminoacid and ornithine decarboxylases
From ovulation to blastocyst attachment. A review of early embryonic life iin the mouse
Folia Vet. Lat.
Effects d'un inhibiteur de la synthèse des polyamines sur la morphogenèse chez l'Oursin, le Chétoptère et l'Algue Acetabularia
Comt. Rend. Ser. D.
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
Biochem. J.
Polyamines and nucleic acids during development of the chick embryo
Biochem. J.
What do the polyamines do?
Nature
Ornithine decarboxylase and Sadenosyl-L-methionine decarboxylase in the decidualizing mouse uterus
Cited by (66)
Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance
2022, Cell ReportsCitation Excerpt :Moreover, consistent with the increased spermidine level during KSHV de novo infection (Figure 1D), hypusinated eIF5A level was gradually increased until 72 hpi and subsided back to basal level at 96 h of KSHV de novo infection (Figure 2B). Treatment of 2-difluoromethylornithine (DFMO), an inhibitor of ODC (Fozard et al., 1980), significantly reduced the level of eIF5A hypusination in KSHV-infected TIME cells in both 2D and 3D culture conditions, indicating that polyamine biosynthesis directly contributes to the level of eIF5A hypusination upon KSHV infection (Figure 2C). As hypusinated eIF5A has a different isoelectric point from the unhypusinated form, isoelectric focusing gel with anti-eIF5A immunoblotting revealed two distinct bands, the upper band corresponding to the hypusinated eIF5A and the lower band to the unhypusinated eIF5A (Figure 2D).
Nutrition influence on sow reproductive performance and conceptuses development and survival: A review about L-arginine supplementation
2019, Livestock ScienceCitation Excerpt :Nitric oxide and polyamines (putrescine, spermidine and spermine), in association with insulin-like growth factor (IGF), vascular endothelial growth factor and other growth factors, play important roles in placental and conceptuses growth during gestation (Wu et al., 2010), being crucial for angiogenesis, embryogenesis, and fetal development (Reynolds and Redmer, 2001; Satterfield and Dunlap, 2013; Wu et al., 2006; Wu and Meininger, 2009). In addition, both NO (Biswas et al., 1998; Chwalisz and Garfield, 2000; Manser et al., 2004; Ota et al., 1999) and polyamines (Fozard et al., 1980) are involved in embryo implantation through mechanisms that have not yet been completely elucidated, but are probably related to the mTOR signaling pathway (Martin, 2003; Zeng et al., 2013). Polyamines also regulate DNA and protein synthesis in mammals’ placenta, uterus and fetuses through mTOR pathway, and are, therefore, necessary for cell proliferation, migration and differentiation (Flynn et al., 2002; Ishida et al., 2002; Kong et al., 2012) (See Fig. 1).
Transcriptomic Analysis of Polyamine-Related Genes and Polyamine Levels in Placenta, Yolk Sac and Fetus During the Second Half of Mouse Pregnancy
2009, PlacentaCitation Excerpt :Many pharmacological and genetic results have clearly shown that ODC and polyamines are essential for embryonic development in both invertebrate and vertebrate animals [24–31]. In rodents, α-difluoromethylornithine (DFMO), an ODC specific inhibitor, exerted marked contragestational effects when administered, during a critical period after implantation [26,27,32–34]. On the other hand, when this inhibitor was given during the second half of pregnancy no contragestational effect was produced, although small decreases in body and brain weight were observed [35–37].
Reversible changes in goldfish brain polyamine concentrations and synthetic enzymes after cold exposure
2004, Brain ResearchCitation Excerpt :Even though considerable progress has been made during the last years in our understanding of their physiological function, many questions remain unanswered. Polyamines are ubiquitously found in all living cells and from mammals to invertebrates, they have critical functions in supporting cell growth and differentiation [3,11,20,25,52]. Polyamines are also implicated in normal growth and differentiation of CNS [51], and recent studies suggest they might influence neuronal growth, migration, and synaptic plasticity by modulating NMDA receptors [21].
Analysis of polyamines as markers of (patho)physiological conditions
2002, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences