Rapid communicationThe nucleus reticularis gigantocellularis of the medulla oblongata is a highly sensitive site in the production of morphine analgesia in the rat
References (4)
- et al.
Stereotaxic atlases for the cat, rabbit and rat
- et al.
Effects of morphine, L-dopa and tetrabenazine on the lamina V cells of spinal dorsal horn
Life Sci.
(1975)
Cited by (115)
The antinociceptive effect of anterior pretectal nucleus stimulation is mediated by distinct neurotransmitter mechanisms in descending pain pathways
2019, Brain Research BulletinCitation Excerpt :Various neurochemicals participate in pain mediation in the aforementioned structures. Injection of d,l-homocysteic acid (Lovick, 1986) or opiates (Takagi et al., 1977; Kaneko et al., 1983) into the LPGi induces analgesia in rats. The LPGi contains enkephalin terminals and neurons (Takagi et al., 1978; Hokfelt et al., 1979; Menetrey and Basbaum, 1987), glutamate neurons (Kihara and Kubo, 1991) and serotonergic cells (Skagerberg and Björklund, 1985; Chen et al., 2003).
Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP2A and PP5 estimated by tail-pinch test in mice
2005, Brain ResearchCitation Excerpt :Pain can be also controlled by central mechanisms, of which a representative example is the descending inhibitory pathway arising in the midbrain periaqueductal gray (PAG) and projecting to the dorsal horn of spinal cord through the nucleus raphe magnus and the nucleus reticularis gigantocellularis. Microinjection of low dose of opiates directly into specific regions of the ascending pain pathway, and inhibitory descending pathway produces a powerful antinociception by inhibiting the activity of the nociceptive neurons [20]. PAG and the dorsal horn of spinal cord are the most sensitive regions to morphine of those pathways.
Itch-associated response and antinociception induced by intracisternal endomorphins in mice
1998, Japanese Journal of PharmacologyChapter 28. Role of polymodal receptors in the acupuncture-mediated endogenous pain inhibitory systems
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