Clinical and laboratory noteNote on a possible correspondence between the scotomas of migraine and spreading depression of Leão
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2020, Progress in Brain ResearchCitation Excerpt :Since the original publications of Leao (Leao, 1944, 1947), experimental CSD has been recorded in the cortices across different classes of animals from lissencephalic (e.g., rodents or rabbits) (Bowyer et al., 1999a) to gyrencephalic (e.g., feline or swine) brains (Bowyer et al., 1999b; James et al., 1999; Santos et al., 2013). In 1958, Milner reported that what Lashley speculated may be what Leao observed (Milner, 1958). In 2001, Hadjikhani et al. captured a CSD-like wave in migraineurs using functional magnetic resonance imaging (fMRI).
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