Clinical and laboratory note
Note on a possible correspondence between the scotomas of migraine and spreading depression of Leão

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Abstract

By plotting his own scotomas at regular intervals during migraine attacks, Lashley came to the conclusion that a disturbance was advancing at about 3 mm/min. over the visual cortex. The apparent nature of the disturbance, and its rate of advance, correspond closely to those of a spreading depression observed by Leão in the cortical activity of rabbits, cats and monkeys. If these two phenomena are indeed related, the fact may suggest a means of improving migraine therapy.

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    Citation Excerpt :

    Since the original publications of Leao (Leao, 1944, 1947), experimental CSD has been recorded in the cortices across different classes of animals from lissencephalic (e.g., rodents or rabbits) (Bowyer et al., 1999a) to gyrencephalic (e.g., feline or swine) brains (Bowyer et al., 1999b; James et al., 1999; Santos et al., 2013). In 1958, Milner reported that what Lashley speculated may be what Leao observed (Milner, 1958). In 2001, Hadjikhani et al. captured a CSD-like wave in migraineurs using functional magnetic resonance imaging (fMRI).

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