Brief noteClonal analysis of mesoderm induction in Xenopus laevis
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Cited by (109)
The organizer: What it meant, and still means, to developmental biology
2024, Current Topics in Developmental BiologyNeural stem cell heterogeneity in the mammalian forebrain
2018, Progress in NeurobiologyCitation Excerpt :Supporting the default pathway idea, embryonic microscopy studies involving tissue‐specific gene ablation, null-mutant mice, and the generation of mutant chimeras (Stottmann and Klingensmith, 2011; Kimura-Yoshida et al., 2015; Varlet et al., 1997) have shown that the neural fate results from the suppression of an epidermal fate via a signal generated by a group of cells within the primitive streak termed Hensen's node (reviewed in Niehrs, 2004). Further support comes from observation of low density ectodermal cell cultures and single cell-derived colonies in which the majority of cells express neural genes and have neural morphology (Godsave and Slack, 1989; Sato and Sargent, 1989; Tropepe et al., 2001). Perhaps the most compelling evidence is that ESCs grown in minimal conditions (i.e. in the absence of exogenous factors) will take on a neural fate, suggesting the cells are “defaulting” to the neural lineage (Smukler et al., 2006).
Ventricular cell fate can be specified until the onset of myocardial differentiation
2016, Mechanisms of DevelopmentCitation Excerpt :However, our data shows that BMP inhibition rescues proepicardial cell fate as well, arguing that BMP signalling has an additional instructive role in cardiac cell fate diversification. Animal pole ectodermal explants are known to contain BMP ligands, and their removal by dissociation (Godsave and Slack, 1989; Grunz and Tacke, 1989) or blocking by secreted antagonist Noggin (Lamb et al., 1993) induces neural cell fate. Here we have shown that expression of GATA4 in intact animal caps induces panmyocardial, ventricular and proepicardial cell fates, suggesting that endogenous BMP is at least permissive for the process.
Self-formation of layered neural structures in three-dimensional culture of ES cells
2012, Current Opinion in NeurobiologyCitation Excerpt :These neural inducers bind to BMP factors in the extracellular space and inactivate BMP signaling, which otherwise suppresses neural differentiation. In the absence of neural-differentiation inhibitors, pluripotent animal cap cells undergo differentiation into neural progenitors and this mode of intrinsic differentiation is called the neural-default model [5,11–14]. The same principle, involving fly homologs of Chordin and BMP4, is shown to work in neuroectodermal development of the Drosophila embryo [15–19].
Neural induction in the absence of organizer in salamanders is mediated by MAPK
2007, Developmental BiologySensory Organs: Making and Breaking the Pre-Placodal Region
2005, Current Topics in Developmental BiologyCitation Excerpt :In the 1990s, experiments in Xenopus led to the proposal that signaling via the bone morphogenetic protein (BMP) pathway plays a key role in ectodermal patterning and that neural plate formation requires BMP inhibition. If animal caps isolated from blastula stage embryos are first dissociated, neural tissue forms after reaggregation (Godsave and Slack, 1989; Grunz and Tacke, 1989; Sato and Sargent, 1989); therefore, the “default” state of these cells has been considered to be “neural.” In the same assay, activation of the BMP pathway leads to upregulation of epidermal markers, but loss of neural markers (Suzuki et al., 1997a,b; Wilson and Hemmati‐Brivanlou, 1995; Wilson et al., 1997).