Pharmacokinetic and pharmacodynamic investigations with monthly injectable contraceptive preparations☆
References (22)
- et al.
A comparison of the pharmacokinetic profiles of three estradiol esters
Contraception
(1980) - et al.
Assessment of the specificity of norethisterone radioimmunoassays
J Steroid Biochem
(1978) - et al.
Dating the endometrial biopsy
Fertil Steril
(1950) - et al.
Morphometric analysis of the human endometrium in relation to peripheral hormone levels
Fertil Steril
(1982) - et al.
Return of ovulatory cyclicity following an intramuscular injection of medroxyprogesterone acetate (Provera)
Contraception
(1974) - et al.
Pharmacokinetic study of different doses of Depo-Provera
Contraception
(1980) - et al.
Hormonal effects of the 300 μg norethisterone (NET) minipill. 1. Daily steroid levels in 43 subjects during a pretreatment cycle and during the second month of NET administration
Contraception
(1980) - et al.
Metabolic fate of a long-acting injectable estrogen-progestogen contraceptive
Contraception
(1973) - et al.
Pharmacokinetic and pharmacodynamic studies with vaginal devices releasing norethisterone at a constant, near zero order
Contraception
(1981) - et al.
Pharmacokinetic and pharmacodynamic investigations with vaginal releasing levonorgestrel at a constant, near zero order rate
Contraception
(1982)
Long-acting contraceptive implants: an analysis of menstrual bleeding patterns
Contraception
Cited by (52)
Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception
2021, Pharmacology and TherapeuticsMedroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: Steady-state pharmacokinetics
2013, ContraceptionCitation Excerpt :This peak simulated the pre-ovulatory peak in a normal menstrual cycle and returned to baseline levels approximately 14–24 days post-injection, without a subsequent ovulatory peak in serum P [16]. MPA levels peaked in the first week after injection and became undetectable 28–90 days after the third injection [6,7,16]. We did find higher AUC values for E2 than Rahimy et al. [11].
Comparative pharmacokinetics and pharmacodynamics after subcutaneous and intramuscular administration of medroxyprogesterone acetate (25 mg) and estradiol cypionate (5 mg)
2011, ContraceptionCitation Excerpt :The once-a-month combined injectable contraceptives are highly effective. The cumulative pregnancy rate for 100 women-years is 0.4 with NET-EN 50 mg+E2-Val 5 mg and from 0 to 0.2 for 100 women-years with the combination MPA 25 mg+E2-Cyp 5 mg [1–5]. Because of the short time in clearing MPA from circulation, ovulation and fertility are recovered 60–90 days after the last injection [5,6].
Egon R. Diczfalusy, the discovery of the fetoplacental unit and much more
2011, Contraception
- ☆
A preliminary report has been presented at the Second Annual Meeting of SAC, Jakarta, November, 1984.
- 2)
Present address: Department of Obstetrics and Gynecology, University of Basel, Switzerland.