A calculation of percutaneous drug absorption—I. Theoretical

Abstract

Several theoreticals for simulating percutaneous drug absorption with a computer aid are proposed. By using our theoreticals, the simulation can be made for the process not only during an ointment application but also after its removal. The flow rate of drug from vehicle to skin and that from skin to blood also be estimated. In addition, we defined an apparent length of diffusion, l_d and showed how to assess l_d. The effect of a change in regional blood flow on drug flux from the skin at the quasi-steady-state is discussed.