Distribution of diamine oxidase and imidazole-N-methyltransferase along the gastrointestinal tract

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Abstract

  • 1.

    1. Gastrointestinal distribution of diamine oxidase (DAO), imidazole-N-methyl transferase (IMIT) and histamine was studied in six mammalian species.

  • 2.

    2. DAO was high in the small intestine, low in the large intestine with the exception of the dog and practically absent in the stomach. In general, herbivores have lower DAO than either omnivores or carnivores.

  • 3.

    3. IMT activity was present all along the gastrointestinal tract with the exception of the rat stomach. In dogs, IMT activity was higher in the pyloric gland area than in the oxyntic gland area but the reverse was found in rabbits and guinea pigs.

  • 4.

    4. Germ-free rats showed similar DAO and IMT activity distribution in the small intestine as normal rats.

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