ReviewThe metabolism and DNA binding of the cooked-food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in precision-cut rat liver slices
References (65)
- et al.
Cocaine hepatotoxicity in cultured liver slices: a species comparison
Toxicology
(1990) - et al.
Predictive value of liver slices for metabolism and toxicity in vivo: use of acetaminophen as a model hepatotoxicant
Toxicol. Appl. Pharmacol.
(1993) - et al.
A new instrument for the rapid preparation of tissue slices
Anal. Biochem.
(1980) - et al.
Dynamic organ culture of precision-cut liver slices for in vitro toxicology
Life Sci.
(1985) Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process
Mutat. Res.
(1985)- et al.
Role of sulfation and acetylation in the activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA
Mutat. Res.
(1990) - et al.
Use of pentachlorophenol as long-term inhibitor of sulfation of phenols and hydroxamic acids in the rat in vivo
Biochem. Pharmacol.
(1983) - et al.
The metabolic disposition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the induced mouse
Food Chem. Toxicol.
(1989) - et al.
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
J. Biol. Chem.
(1964) - et al.
The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties
J. Biol. Chem.
(1964)
Viability measurements in mammalian systems
Anal. Biochem.
(1989)
Protein measurements with folin phenol reagent
J. Biol. Chem.
(1951)
The culture of mature organs in a synthetic medium
Exp. Cell Res.
(1959)
The pharmacokinetics and metabolism of pentachlorophenol in rats
Toxicol. Appl. Pharmacol.
(1977)
Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavinoids
J. Biol. Chem.
(1981)
Inhibition of benzo[a]pyrene monooxygenase by α-naphthoflavone may be partially mediated by the metabolite 9-hydroxy-α-naphthoflavone
Toxicol. Lett.
(1982)
Cyclosporin A metabolism in human liver, kidney and intestine slices, Comparison to rat and dog slices and human cell lines
Drug Metab. Dispos.
(1992)
The biotransformation of the ergot derivative CQA 206–291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance
Drug Metab. Dispos.
(1993)
Liver slices in dynamic organ culture. II. An in vitro cellular technique for the study of integrated drug metabolism using human tissue
Xenobiotica
(1991)
Versuche an überlebendem Carcinomgewebe (Methoden)
Biochem. Z.
(1923)
Maintenance of adult rat liver slices in dynamic organ culture
In Vitro Cell Dev. Biol.
(1986)
Mutagenesis and carcinogenesis: endogenous and exogenous factors
Environ. Mol. Mutat.
(1989)
The causes of cancer: quantitative estimate of avoidable risks of cancer in the United States today
J. Natl. Cancer Inst.
(1981)
Diet, Nutrition and Cancer
(1982)
Studies on environmental chemical carcinogenesis in Japan
Science
(1986)
Identification of the mutagens in cooked beef
Environ. Health Perspect.
(1986)
Method for detecting carcinogens and mutagens with the Salmonella/mammalian-microsomal mutagenicity test
Mutat. Res.
(1975)
The isolation and identification of a new mutagen from fried ground beef: 2-am no-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Carcinogenesis
(1986)
Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity
Mutagenesis
(1987)
Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxyamino-PhIP, a directly acting genotoxic metabolite
Carcinogenesis
(1989)
Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-A]pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 1A2
Mutagenesis
(1991)
Cited by (6)
Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1 -methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC)
1997, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisHandbook of biotransformations of aromatic compounds
2004, Handbook of Biotransformations of Aromatic Compounds
Copyright © 1995 Published by Elsevier Ireland Ltd.