Elsevier

Brain Research

Volume 683, Issue 1, 12 June 1995, Pages 149-152
Brain Research

Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

https://doi.org/10.1016/0006-8993(95)00351-PGet rights and content

Abstract

Microinjection ofl-glutamate (109 mM; 12–18nl) or AMPA (150–300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

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