Elsevier

Brain Research

Volume 660, Issue 2, 17 October 1994, Pages 333-336
Brain Research

Short communication
The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

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Abstract

We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21–22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.

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This work was supported by USPHS Grant AG04418 and the VAMRS.

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