Thalamically projecting cells of the lateral cervical nucleus in monkey

doi:10.1016/0006-8993(91)90853-N

Brain Research

Volume 555, Issue 1, 26 July 1991, Pages 10-18

https://doi.org/10.1016/0006-8993(91)90853-N Get rights and content

Abstract

The number, location, and morphology of thalamically projecting lateral cervical nucleus (LCN) cells were determined in monkey using retrograde transport of wheatgerm agglutinin-conjugated horseradish peroxidase. These data were compared to the total population of LCN neurons as determined by Nissl stain. In 4Macaca fascicularis and oneSaimiri sciureus the average size of the thalamic projection from LCN was found to be 506 ± 94 cells contralateral to the injections. Thalamically projecting LCN neurons were located between the lower medulla and the third cervical segment; approximately 90% of these cells were in the first two cervical segments. Morphologic analysis of thalamically average total number of LCN cells was determined to be 1617 ± 908 on one side, in Nissl material. In these Nissl-stained preparations LCN neurons were found as far caudal as the fourth cervical segment; 68% were located in the first two cervical segments. Hence, thalamically projecting LCN neurons in the monkey are located in the rostral portion of the nucleus and comprise about one-third of the total population. Comparison of these data with reports in the literature imply that, unlike the cat, the major projection from LCN in monkeys is to the mesencephalon rather than to the thalamus.

References (57)

BerkleyK.J. et al.
Differences in the collateralization of neuronal projections from the dorsal column nuclei and lateral cervical nucleus to the thalamus and tectum in the cat: an anatomical study using two different double-labeling techniques
Brain Research
(1980)
BlomqvistA. et al.
Tectal and thalamic projections of dorsal column and lateral cervical nuclei: a quantitative study in the cat
Brain Research
(1978)
BoivieJ.
The termination of the cervicothalamic tract in the cat. An experimental study with silver impregnation methods
Brain Research
(1970)
BoivieJ.
Thalamic projections from lateral cervical nucleus in monkey. A degeneration study
Brain Research
(1980)
BryanR.N. et al.
Cells of origin of the spinocervical tract in the monkey
Exp. Neurol.
(1974)
KemplayS.K. et al.
A qualitative and quantitative analysis of the distributions of cells in the spinal cord and spinomedullary junction projecting to the thalamus of the rat
Neuroscience
(1986)
LimaD. et al.
The spinothalamic system of the rat: structural types of retrogradely labelled neurons in the marginal zone (lamina I)
Neuroscience
(1988)
PechuraC.M. et al.
Spinal neurons which project to the periaqueductal gray and the medullary reticular formation via axon collaterals: a double-label fluorescence study in the rat
Brain Research
(1986)
WestmanJ.
The lateral cervical nucleus in the cat. I. A Golgi study
Brain Research
(1968)
WibergM. et al.
The spinomesencephalic tract in the cat: its cells of origin and termination pattern as demonstrated by the intraaxonal transport method
Brain Research
(1984)

AbercrombieM.

Estimation of nuclear population from microtome sections

Anat. Rec.

(1966)

ApkarianA.V. et al.

The primate spinothalamic pathways: II. The cells of origin of the dorsolateral and ventral spinothalamic pathways

J. Comp. Neurol.

(1989)

ApkarianA.V. et al.

The primate spinothalamic pathways: I. A quantitative study of the cells of origin of the spinothalamic pathway

J. Comp. Neurol.

(1989)

BakerM.L. et al.

Anatomical studies of the spinocervical tract of the rat

Somatosens. Res.

(1984)

BerkleyK.J.

Spatial relationships between the terminations of somatic sensory and motor pathways in the rostral brainstem of cats and monkeys. I. Ascending somatic sensory inputs to lateral diencephalon

J. Comp. Neurol.

(1980)

BerkleyK.J. et al.

Projections to the inferior olive of the cat. I. Comparisons of input from the dorsal column nuclei, the lateral cervical nucleus, the spino-olivary pathways, the cerebral cortex and the cerebellum

J. Comp. Neurol.

(1978)

Bjo¨rklundM. et al.

Lateral cervical nucleus of monkey and its projection to the thalamus

Neuroscience

(1982)

BoivieJ.

Anatomic and physiologic features of the spinocervico-thalamic pathway

BromanJ. et al.

Substance P-like immunoreactivity in the lateral cervical nucleus of the owl monkey (Aotus trivirgatus): a comparison with the cat and rat

J. Comp. Neurol.

(1989)

BromanJ. et al.

Serotonergic innervation of the lateral cervical nucleus: an immunohistochemical study in cats and monkeys (Aotus trivirgatus)

Synapse

(1990)

BrownA.G. et al.

Responses of spinocervical tract neurones to natural stimulation of identified cutaneous receptors

Exp. Brain Res.

(1969)

BrownA.G. et al.

The density, distribution and topographical organization of spinocervical tract neurones in the cat

J. Physiol.

(1980)

CarstensE. et al.

Anatomical and physiological properties of ipsilaterally projecting spinothalamic neurons in the second cervical segment of the cat's spinal cord

J. Comp. Neurol.

(1978)

CarstensE. et al.

Laminar origins of spinothalamic projections in the cat as determined by the retrograde transport of horseradish peroxidase

J. Comp. Neurol.

(1978)

ChenZ.-Y. et al.

Experimental studies on the nucleus cervical lateralis (NCL) ofMacaca cyclopis (Swinhoe). Part I: The general morphology and the spinal cord origins of the nucleus cervicalis lateralis of the monkey (Macaca cyclopis)

J. Formosan. Med. Assoc.

(1971)

CraigA.D.

Spinal and medullary input to the lateral cervical nucleus

J. Comp. Neurol.

(1978)

CraigA.D. et al.

The lateral cervical nucleus in the cat: anatomic organization of cervicothalamic neurons

J. Comp. Neurol.

(1979)

CraigA.D. et al.

Organization of anterogradely labeled spinocervical tract terminations in the lateral cervical nucleus of the cat

J. Comp. Neurol.

(1987)

Cited by (11)

Projections from the Spinal Cord to the Brain
2009, The Spinal Cord
This chapter deals with projections that originate from the spinal cord and descent that brain to spinal cord. The ascending spinal projections connect the spinal cord to supraspinal levels and transmit sensory information such as pain, temperature, position sense, and touch from somatic structures and pressure, pain and visceral information from internal organs. Spinal cord neurons project to the brainstem, cerebellum, midbrain, diencephalons, and telencephalon. Some projections, such as the postsynaptic dorsal column pathway and the spinocervical pathway, synapse with second-order neurons, which in turn project to higher centers. Some of the projections are directly to supraspinal structures, such as the spinothalamic, spinomesencephalic, and spinohypothalamic tracts. Ascending spinal projections are composed of mostly myelinated dorsal root fibers from the dorsal root ganglia and axons of spinal neurons. Anatomically, the ascending spinal projections are located in the ventral, lateral and dorsal funiculi on each side of the spinal cord. In experimental animals, electrophysiological studies and anatomical tract tracing methods using tracers and Wallerian degeneration technique have collectively provided extensive and accurate information on ascending spinal projections. In humans, on the contrary, information is limited to data obtained from patients with localized traumatic and inflammatory spinal lesions, or surgical interventions.
Separate, parallel sensory and hedonic pathways in the mammalian somatosensory system
2002, Brain Research Bulletin
We propose that separate sensory and hedonic representations exist in each of the primary structures of the somatosensory system, including brainstem, thalamic and cortical components. In the dorsal horn of the spinal cord, the hedonic representation, which consists primarily of nociceptive-specific, wide dynamic range, and thermoreceptive neurons, is located in laminae I and II, while the sensory representation, composed primarily by low-threshold and wide dynamic range neurons, is found in laminae III through V. A similar arrangement is found in the caudal spinal trigeminal nucleus. Based on the available anatomical and electrophysiological data, we then determine the corresponding hedonic and sensory representations in the area of the dorsal column nuclei, ventrobasal and posterior thalamic complex, and cortex. In rodent primary somatosensory cortex, a hedonic representation can be found in laminae Vb and VI. In carnivore and primate primary and secondary somatosensory cortical areas no hedonic representation exists, and the activities of neurons in both areas represent the sensory aspect exclusively. However, there is a hedonic representation in the posterior part of insular cortex, bordering on retroinsular cortex, that receives projections from two thalamic areas in which hedonics are represented. The functions of the segregated components of the system are discussed, especially in relation to the subjective awareness of pain.
Anatomical organization of the lateral cervical nucleus in Artiodactyls
2021, Veterinary Research Communications
Neuroanatomy of pain and pain pathways
2013, Handbook of Pain and Palliative Care: Biobehavioral Approaches for the Life Course
The human pain system: Experimental and clinical perspectives
2010, The Human Pain System: Experimental and Clinical Perspectives
The neuroanatomy of pain and pain pathways
2009, Biobehavioral Approaches to Pain

View all citing articles on Scopus

View full text

Thalamically projecting cells of the lateral cervical nucleus in monkey

Abstract

Brain Research

Brain Research

Brain Research

Brain Research

Exp. Neurol.

Neuroscience

Neuroscience

Brain Research

Brain Research

Brain Research

Estimation of nuclear population from microtome sections

Anat. Rec.

The primate spinothalamic pathways: II. The cells of origin of the dorsolateral and ventral spinothalamic pathways

J. Comp. Neurol.

The primate spinothalamic pathways: I. A quantitative study of the cells of origin of the spinothalamic pathway

J. Comp. Neurol.

Anatomical studies of the spinocervical tract of the rat

Somatosens. Res.

Spatial relationships between the terminations of somatic sensory and motor pathways in the rostral brainstem of cats and monkeys. I. Ascending somatic sensory inputs to lateral diencephalon

J. Comp. Neurol.

Projections to the inferior olive of the cat. I. Comparisons of input from the dorsal column nuclei, the lateral cervical nucleus, the spino-olivary pathways, the cerebral cortex and the cerebellum

J. Comp. Neurol.

Lateral cervical nucleus of monkey and its projection to the thalamus

Neuroscience

Anatomic and physiologic features of the spinocervico-thalamic pathway

Substance P-like immunoreactivity in the lateral cervical nucleus of the owl monkey (Aotus trivirgatus): a comparison with the cat and rat

J. Comp. Neurol.

Serotonergic innervation of the lateral cervical nucleus: an immunohistochemical study in cats and monkeys (Aotus trivirgatus)

Synapse

Responses of spinocervical tract neurones to natural stimulation of identified cutaneous receptors

Exp. Brain Res.

The density, distribution and topographical organization of spinocervical tract neurones in the cat

J. Physiol.

Anatomical and physiological properties of ipsilaterally projecting spinothalamic neurons in the second cervical segment of the cat's spinal cord

J. Comp. Neurol.

Laminar origins of spinothalamic projections in the cat as determined by the retrograde transport of horseradish peroxidase

J. Comp. Neurol.

Experimental studies on the nucleus cervical lateralis (NCL) ofMacaca cyclopis (Swinhoe). Part I: The general morphology and the spinal cord origins of the nucleus cervicalis lateralis of the monkey (Macaca cyclopis)

J. Formosan. Med. Assoc.

Spinal and medullary input to the lateral cervical nucleus

J. Comp. Neurol.

The lateral cervical nucleus in the cat: anatomic organization of cervicothalamic neurons

J. Comp. Neurol.

Organization of anterogradely labeled spinocervical tract terminations in the lateral cervical nucleus of the cat

J. Comp. Neurol.