Harmaline-induced tremor in the rat: Abolition by 3-acetylpyridine destruction of cerebellar climbing fibers
References (11)
Histological evidence supporting the inferior olive as the major source of cerebellar climbing fibers in the rat
Brain Research
(1974)- et al.
Effects of 3-acetylpyridine on the central nervous system of the rat as demonstrable by silver methods
Brain Research
(1974) - et al.
Climbing fiber differentiation: its action on Purkinje cell dendritic spines
Brain Research
(1975) - et al.
Inhibition by diazepam of the tremor and the increase of cerebellar cGMP content elicited by harmaline
Brain Research
(1975) - et al.
The molecular layer of the adult cat cerebellar cortex after lesions of the parallel fibers: an optic and electron microscopic study
Brain Research
(1969)
Cited by (63)
Is the inferior olive central to essential tremor? Yes
2022, International Review of NeurobiologyCitation Excerpt :Not surprisingly, the same brain structures required for rhythmic activity in this axis are required for harmaline tremor. The tremor is abolished by lesions of IO (Sharabi et al., 2019; Simantov, Snyder, & Oster-Granite, 1976), or when the IO ceases to respond to repeated harmaline with burst-firing (Lorden, Stratton, Mays, & Oltmans, 1988), or when gap junction blockers are administered (Martin & Handforth, 2006). Genetic strains that lack normal CSs, such as dystonic rats (LeDoux & Lorden, 2002) or Kv3.3 KO mice (Hurlock, McMahon, & Joho, 2008; Zagha, Lang, & Rudy, 2008) fail to show tremor (Lorden, Oltmans, McKeon, Lutes, & Beales, 1985; McMahon et al., 2004; Stratton & Lorden, 1991).
Potential mechanisms of tremor tolerance induced in rats by the repeated administration of total alkaloid extracts from the seeds of Peganum harmala Linn
2020, Journal of EthnopharmacologyCitation Excerpt :In addition to various neurotransmitters, the function of the olivocerebellar system can also influence the tremor response (Handforth, 2012; Miwa, 2007). The tremor-inducing effects of harmaline in rats are lost when ION neurons are destroyed by 3-acetylpyridine (Simantov et al., 1976). The tremor-generating action of harmaline is also lost in mutant mice with Purkinje cell degeneration (Milner et al., 1995).
Use of the Harmaline and α1 Knockout Models to Identify Molecular Targets for Essential Tremor
2015, Movement Disorders: Genetics and Models: Second EditionGenetics of essential tremor: From phenotype to genes, insights from both human and mouse studies
2014, Progress in NeurobiologyCitation Excerpt :Harmaline is considered as a GABAA receptor inverse agonist that serves in an inducible ET rodent model (Wilms et al., 1999). In this case, the tremor is primarily mediated through the action of harmaline on inferior olive neurons (ION) which are found in a brain region of the motor related medulla, and have excitatory projections to PC of the cerebellar cortex (Batini et al., 1979, 1981; De Montigny and Lamarre, 1975; Milner et al., 1995; Simantov et al., 1976). This phenomenon causes enhanced neuronal synchrony and rhythmicity in the olivocerebellar system, generating tremors (Miwa, 2007).
Harmaline Tremor Model
2010, Encyclopedia of Movement Disorders, Three-Volume SetHarmaline Tremor Model
2010, Encyclopedia of Movement Disorders
This research was supported in part by USPHS Grants NS-08997 (to R.M.H.), MH-18501, RSDA MH-33128 (to S.H.S.) and an Eleanor Roosevelt fellowship (to R.S.).
- *
The authors would like to thank J. Firman for his technical assistance.