Anatomical and electrophysiological identification of a projection from the mesencephalic raphe to the caudate-putamen in the rat
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From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment
2022, Handbook of Clinical NeurologySerotonergic regulation of the dopaminergic system: Implications for reward-related functions
2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :But the most important interconnection linking the serotonergic system with reward function is the one with the dopaminergic system, dopamine (DA) being the well-recognized neurotransmitter involved in reward processing (Schultz, 1997; Schultz et al., 1997; Wise, 1996). The RN project massively to the ventral tegmental area (VTA) and to the substantia nigra (Herve et al., 1987; Miller et al., 1975; Vertes, 1991; Watabe-Uchida et al., 2012). The RN also receive, although to a lesser extent, projections back from the dopaminergic system (Kalen et al., 1988) (Ogawa et al., 2014; Vertes and Linley, 2008).
Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases
2021, Progress in Brain ResearchCitation Excerpt :However, it remains unclear whether the CRF-containing neurons themselves, or the serotonergic DRN neurons they target, send collaterals to CeA and PVN. Early studies showed that most DRN neurons project ipsilaterally, with only a few contralaterally (Miller et al., 1975). A retrograde tracing experiment showed that when DRN efferents to the entorhinal cortex were found, contralateral terminals are preferentially located close to the midline (Köhler and Steinbusch, 1982).
Pharmacological animal models of Tourette syndrome
2013, Neuroscience and Biobehavioral ReviewsThe serotonergic system in Parkinson's disease
2011, Progress in NeurobiologyCitation Excerpt :A minority of serotonergic neurons are also found outside of the raphe complex (Poitras and Parent, 1978; Sladek et al., 1982). Raphe nuclei provide 5-HT innervation to the entire brain, including the substantia nigra (SN) (Dray et al., 1976; Fibiger and Miller, 1977; Imai et al., 1986; Lavoie and Parent, 1990), striatum (Imai et al., 1986; Lavoie and Parent, 1990; Miller et al., 1975; Pasik and Pasik, 1982; Steinbusch et al., 1980; van der Kooy and Hattori, 1980), globus pallidus (GP) (Charara and Parent, 1994; Lavoie and Parent, 1990), subthalamic nucleus (STN) (Lavoie and Parent, 1990; Mori et al., 1985), thalamus (Moore et al., 1978) and cortex (Bobillier et al., 1976; Seguela et al., 1989), the core structures of the cortico-basal ganglia-thalamo-cortical loop (Parent and Hazrati, 1995a,b), the physiology of which is disrupted in PD (DeLong, 1990; DeLong and Wichmann, 2007; Parent et al., 2000). The classic model of the basal ganglia circuitry is depicted in Fig. 1.
This work was supported by grants from the Medical Research Council of Canada to J.J.M., H.C.F. and H. McL.
The technical assistance of H. Brandejs and S. Atmadja is appreciated.
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Scholars of the Medical Research Council of Canada.