Research paperHuman liver oxidative metabolism of O6-benzylguanine
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2001, Biochemical PharmacologyCitation Excerpt :Debenzylation by CYP1A2 displayed an apparent Km value of 35.9 μM and a Vmax of 0.59 pmol/min/pmol of CYP1A2. BG is oxidized to 8-oxoBG by CYP1A2, CYP3A4, and aldehyde oxidase [28]. The Km and Vmax for BG oxidation by CYP1A2 is 1.3 μM and 1.7 pmol/min/pmol of CYP1A2, respectively [28].
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