Functional expression of intestinal dipeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes
References (34)
- et al.
Evidence for a single common carrier for uptake of a dipeptide and a tripeptide by hamster jejunum in vitro
Gastroenterology
(1976) - et al.
Peptide transport in rabbit intestinal brush-border membrane vesicles studied with a potential-sensitive dye
Biochim Biophys Acta
(1985) - et al.
Proton gradient-coupled uphill transport of glycylsarcosine in rabbit renal brush-border membrane vesicles
Biochem Biophys Res Commun
(1985) - et al.
Proton-coupled transport of glycylglycine in rabbit renal brush-border membrane vesicles
Biochim Biophys Acta
(1985) - et al.
H+ coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes
J Biol Chem
(1986) - et al.
β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane
Biochem Pharmacol
(1987) - et al.
Characterization of the oral absorption of β-lactam antibiotics II: competitive absorption and peptide carrier specificity
J Pharm Sci
(1989) - et al.
Passive- and carrier-mediated intestinal absorption components of captopril
J Pharm Sci
(1988) - et al.
Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics
Biochim Biophys Acta
(1990) - et al.
Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes
J Biol Chem
(1993)
Functional expression of the intestinal peptide-proton co-transporter in Xenopus laevis oocytes
J Biol Chem
(1991)
Direct photoaffinity labeling of binding proteins for β-lactam antibiotics in rabbit intestinal brush border membranes with [3H]benzylpenicillin
Biochem Pharmacol
(1988)
Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles
J Biol Chem
(1984)
Identification of identical binding polypeptides for cepharosporins and dipeptides in intestinal brush-border membrane vesicles by photoaffinity labeling
Biochim Biophys Acta
(1987)
Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and α-amino-β-lactam antibiotics in rabbit small intestine
Biochem Pharmacol
(1993)
Protein-absorption: Development and Present State of the Subject
Is intestinal peptide transport energized by a proton gradient?
Am J Physiol
(1985)
Cited by (30)
pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2
2020, Drug Metabolism and PharmacokineticsCitation Excerpt :As the ratio is much smaller in the oocyte than HEK293 cells, it might need far longer time and/or higher FCCP concentration to evoke sufficient effect of FCCP to alter proton gradient. Another research also reported that 2 h-uptake following 30 min-preincubation of FCCP reduced the uptake activity in the oocyte [33]. Taken together, FCCP seems to be more impotent to eliminate the proton gradient in the oocyte.
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
1998, Biochemical and Biophysical Research CommunicationsOral absorption of β-lactams by intestinal peptide transport proteins
1997, Advanced Drug Delivery ReviewsThe intestinal peptide carrier: A potential transport system for small peptide derived drugs
1996, Advanced Drug Delivery ReviewsDrug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
2016, Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
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Present address: Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
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