Glucocorticoids—uptake by simple diffusion by cultured reuber and novikoff rat hepatoma cells
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2023, Vitamins and HormonesA Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila
2018, Developmental CellCitation Excerpt :It is widely accepted that lipophilic steroid hormones can freely enter and exit cells by simple diffusion across lipid bilayers (Nussey and Whitehead, 2001; Alberts et al., 2015; Urry et al., 2017). This view is supported by previous work on several mammalian steroid hormones (Plagemann and Erbe, 1976; Graff et al., 1977; Giorgi and Stein, 1981). Interestingly, a number of studies also suggested a potential involvement of membrane transporters in cellular uptake of steroid hormones (Milgrom et al., 1973; Rao et al., 1976; Pietras and Szego, 1977).
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2018, Developmental CellCitation Excerpt :Steroids are small, lipophilic molecules that are just “greasy” enough to enter phospholipid bilayers but also just “wet” enough to avoid becoming trapped within membranes. Given these characteristics, it seemed likely that steroid hormones could enter cells by passive diffusion across the plasma membrane, and indeed, several studies came to this very conclusion (Giorgi and Stein, 1981; Gorski and Gannon, 1976; Plagemann and Erbe, 1976). However, other studies suggested that steroid hormones require protein transporters for import into target cells, but no specific transporters were ever identified (Gorski and Gannon, 1976; Milgrom et al., 1973; Pietras and Szego, 1977).
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