Mode of action of alanosine☆
References (7)
- et al.
Archs Biochem. Biophys.
(1956) - et al.
J. biol. Chem.
(1957)
There are more references available in the full text version of this article.
Cited by (37)
EFA(9-β-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine
2006, BloodCitation Excerpt :Furthermore, normal cells abundant in MTAP can be rescued from the toxicity of inhibitors of de novo AMP synthesis by the provision of exogenous MTAP substrates that provide a source of adenine. L-alanosine is a potent inhibitor of de novo AMP synthesis.21-24 The metabolite of L-alanosine, L-alanosinyl-5-amino-4-imidazole carboxylic acid ribonucleotide (L-alanosinyl-AICOR), is a strong inhibitor of adenylosuccinate synthase, which converts IMP to AMP.
ATP depletion affects NPM translocation and exportation of rRNA from nuclei
1996, Biochemical and Biophysical Research CommunicationsMetabolic consequences of adenine-phosphoribosyl transferase deficiency in V79 hamster fibroblasts
1992, Experimental Cell ResearchMetabolism and action of amino acid analog anti-cancer agents
1990, Pharmacology and TherapeuticsAlterations in nucleotide pools induced by 3-deazaadenosine and related compounds role of adenylate deaminase
1988, Biochemical Pharmacology
- ☆
Aided by Grant GM-13958 from the National Institutes of Health, United States Public Health Service.
Copyright © 1968 Published by Elsevier Inc.