Biochemical and Biophysical Research Communications
Role of multiple binding sites in the inhibition of NADH oxidase by piericidin and rotenone
References (16)
- et al.
Biochim. Biophys. Acta
(1965) - et al.
Arch. Biochem. Biophys
(1969) - et al.
J. Biol. Chem
(1968) - et al.
J. Biol. Chem
(1968) - et al.
J. Biol. Chem
(1968) - et al.
J. Biol. Chem
(1962) - et al.
J. Biol. Chem
(1963) - et al.
Biochem. Biophys. Res. Communs
(1966)
Cited by (8)
Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells
2014, Leukemia ResearchCitation Excerpt :Together, these findings suggest that ROT effects on apoptosis induction and mitochondrial depolarization are completed within 30 min of exposure, which is in very good agreement with previous reports that rotenone disrupts Δψm and induces mPTP opening within 20 min (Isenberg and Klaunig, 2000). Our results also indicate that under our conditions the ROT-induced loss of Δψm is reversible, and that Δψm recovery observed after ROT removal may reflect the gradual weakening of rotenone binding to Complex I, which was found to be quite stable, hence persisting a long time upon washing [57]. Both quercetin [21,22,25,40] and menadione (Fig. 2G) were found to decrease the level of NADH in Jurkat cells, suggesting that under our conditions both agents stimulated the activity of respiratory Complex I. Additional results supporting this idea were presented in detail in a recent work [40].
Inhibition of electron and energy transfer in mitochondria by 19-nor-ethynyltestosterone acetate
1970, Archives of Biochemistry and BiophysicsNrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
2010, Molecular and Cellular Biology