A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models

doi:10.1016/0006-291X(83)91659-5

Biochemical and Biophysical Research Communications

Volume 117, Issue 3, 28 December 1983, Pages 740-745

https://doi.org/10.1016/0006-291X(83)91659-5 Get rights and content

Abstract

The cytosolic polypeptides of hepatocyte nodules in six models of liver carcinogenesis were analysed by SDS-polyacrylamide gel electrophoresis and their patterns campared with these of control and variously treated livers. The amount of a polypeptide of M_r 21,000 was about tenfold elevated in the cytosol of five of the six types of nodules and moderately elevated in the sixth. Certain other polypeptides, particularly one of M_r 26,000, also varied in amount, so that all of the nodules analysed could be distinguished from liver by their electrophoretic patterns. Some possible identities of the two polypeptides are discussed. Their study may have mechanistic as well as diagnostic importance.

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A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models

Abstract

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Biochem. Biophys. Res. Commun

Cancer Lett

Cancer Lett

J. Biol. Chem

J. Biol. Chem

Cancer Res

Environ. Hlth Persp

Toxicol. Pathol

Cancer Res