Impairments in availability of insulin to liver in vivo and in binding of insulin to purified hepatic plasma membrane during aging☆

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Abstract

The concentration of insulin in portal vein blood decreases 50–60% in fed or fasted rats as they age from 12- to 24-months. The binding capacity of purified hepatic plasma membrane for insulin decreases approximately 60% as rats age from 2- to 24-months, whereas the dissociation constant for insulin is not altered. It is proposed that these factors may contribute significantly to previously documented examples of age-dependent modifications in liver enzyme regulation.

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    ☆

    part of the thesis of C.F. submitted for the Ph.D. degree to the Dept. of Biochemistry.

    2

    current address: Section of Intermediary Metabolism, NIAMDD, Bethesda, Maryland 20014.

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    Copyright © 1973 Published by Elsevier Inc.