Biochimica et Biophysica Acta (BBA) - Protein Structure
Characteristics and isolation of the phagocytosis-stimulating peptide, tuftsin
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Cited by (80)
Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation
2015, European Journal of Medicinal ChemistryCitation Excerpt :We recently set out a program aimed at the synthesis of new BAT-tuftsin/retro-tuftsin conjugates which were expected to have improved pharmacological features (such as increased water solubility, lowered general toxicity in vivo) and potentially have additional mechanisms of action, including immunostimulatory effect of tuftsin. Tuftsin is a tetrapeptide Thr-Lys-Pro-Arg (TKPR) that been shown to possess immunologic, tumoricidal, and bactericidal activities [12–14]. Accordingly, tuftsin has been successfully used in combination with different antibiotics to treat opportunistic infections caused by bacteria, fungi, and viruses.
Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates
2011, BiomaterialsCitation Excerpt :One major complication for the clinical use of tuftsin is the instability against a battery of enzymes in serum. It has been reported that the biological activity of tuftsin is reduced by LAP, carboxypeptidase B, pronase and subtilisin [25]. The LAP locating on the plasma membrane of human neutrophils, could remove the N-terminal threonine to yield a tripeptide Lys-Pro-Arg, which is an inhibitor of tuftsin activity [26].
Studies of human granulocyte phagocytosis stimulation by tuftsin
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American Cancer Society Professor of Molecular Biology (MA Div.).