Ca2+-induced phase separation in phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine mixed membranes
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Combined force spectroscopy, AFM and calorimetric studies to reveal the nanostructural organization of biomimetic membranes
2014, Chemistry and Physics of LipidsA lipid matrix model of membrane raft structure
2010, Progress in Lipid ResearchRegulation of calcium channel activity by lipid domain formation in planar lipid bilayers
2003, Biophysical JournalCitation Excerpt :Upon elevation of cytosolic Ca2+, RyRs mediate an extensive efflux of Ca2+ from the lumen of sarcoplasmic reticulum to the cytoplasm (Fabiato, 1983; Bers and Perez-Reyes, 1999). Ca2+ is capable of inducing a lateral segregation of phosphatidylserine and other acidic lipids in membranes (Papahadjopoulos et al., 1977; Haverstick and Glaser, 1988; Hinderliter et al., 1994), and this segregation can occur at [Ca2+] ≥ 10−7 M, corresponding to the Ca2+ concentrations in the cytoplasm after RyR/Ca2+-channel stimulation (Tokutomi et al., 1981). Accordingly, it is possible that release of Ca2+ to the cytoplasm leads to formation of domains rich in anionic lipids into the sarcoplasmic membrane.
Strength of Ca<sup>2+</sup> binding to retinal lipid membranes: Consequences for lipid organization
2000, Biophysical JournalCitation Excerpt :Considering the importance of Ca2+ binding to these membranes, it was questioned whether the lateral lipid organization in these membranes is also influenced by Ca2+-lipid interaction. Numerous studies on Ca2+-induced demixing of acidic and zwitterionic phospholipids have been carried out (Hui et al., 1983; Tokutomi et al., 1981; Feigenson, 1989; Coorssen and Rand, 1995; van Dijck et al., 1978; Silvius and Gagne, 1984a,b; Tilcock et al., 1984). It was reported that Ca2+ binding segregates the negatively charged PS into gel-phase domains that are depleted of zwitterionic lipids (Coorssen and Rand, 1995; Feigenson, 1989; Silvius and Gagne, 1984a,b; Hauser and Shipley, 1984; Casal et al., 1987).
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Present address: Division of Biological Regulation, National Institute for Basic Biology, Okazaki 444, Japan.