Steroid production and responsiveness to gonadotropin in isolated stromal tissue of human postmenopausal ovaries☆
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Cited by (64)
A study on steroidogenic elaborations of stroma and their regulation in response to ovarian hormones in goats
2021, Animal Reproduction ScienceCitation Excerpt :The findings from the present study indicated estradiol was involved in the regulation of androgen production by ovarian stromal cells. Reproductively functional animals secrete more steroids as compared to those in the post reproductive state, due toa marked decrease in number of active follicles in the ovary (Laffargue and Serment, 1973; Dennefors et al., 1980; Snowden et al., 1989; Nagamani et al., 1992; Thompson and Adelson, 1993). Also, there have been few studies focused on whether there were estrogen receptors in ovarian stromal cells (D’Haeseleer, 2006) indicating estrogens may have the capacity to stimulate the hormone synthesis by ovarian stroma.
Ovarian Life Cycle
2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth EditionDo anabolic-androgenic steroids have performance-enhancing effects in female athletes?
2018, Molecular and Cellular EndocrinologyCitation Excerpt :However, in postmenopausal women, the ovary becomes a major source of testosterone production and its contribution increases to 50% (Adashi, 1994). Although the climacteric ovary is atrophic and loses its capacity to synthesize estradiol and follicles, it continues to secrete androgens under the stimulation of postmenopausal gonadotropins (Sluijmer et al., 1995; Dowsett et al., 1980; Dennefors et al., 1980). In ovulating women, serum levels of testosterone and androstenedione gradually increase during the follicular phase and peak during the pre-ovulatory phase (Judd and Yen, 1973; Sinha-Hikim et al., 1998).
Ovarian Hormone Synthesis
2015, Endocrinology: Adult and PediatricThe Ovarian Life Cycle
2013, Yen and Jaffe's Reproductive Endocrinology: Seventh EditionOvarian Hormone Synthesis
2010, Endocrinology: Adult and Pediatric, Sixth Edition
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Financial support was obtained from the Swedish Medical Research Council (Project 4982).