Case report
Primary defective iron reutilization: Response to testosterone therapy

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Abstract

Ferrokinetic data in five patients with primary defective iron reutilization before and following testosterone therapy are presented. The anemia in these patients is characterized by hypoferremia, increased iron stores and poor response to iron therapy. Iron utilization as measured by the intravenous injection of Fe59 citrate is normal, whereas iron reutilization as measured by the intravenous injection of Fe55-tagged hemoglobin solution is poor. Iron absorption also is poor. Testosterone therapy increased the total hemoglobin mass and total red cell mass in all patients and improved the reutilization of iron, but not the intestinal absorption of the metal.

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This study was supported by U. S. Public Health Service Grant CA 05554-04 and by Clinical Research Center Grant (FR-72).

1

From the Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania.

Present address: M.R.C. Blood Coagulation Research Unit, The Churchill Hospital, Oxford, England.

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