Case ReportExtramammary Paget's Disease of Scrotum Treated With Radiotherapy
Section snippets
Case Report
A 63-year-old man presented with a 4-year history of erythematous lesions accompanied by an itching sensation on the left side of the scrotum and inguinal area. Physical examination revealed a 7 × 6-cm well-marginated erythematous patch lesion on the left side of the scrotum and inguinal area without palpable inguinal lymph nodes (Fig. 1). The laboratory examination findings were normal. Biopsy of the skin revealed the infiltration of epithelioid cells into the epidermis, often with clear
Comment
EMPD was initially reported in 1889 by Crocker.1 Although the male genitalia was the first extramammary site described, it represents a rare anatomic location, with <30 cases reported.2 The diagnosis of EMPD can be made by skin biopsy of the lesion. Because a greater incidence of internal malignancy has been noted in the urinary tract, urethrocystoscopy, transrectal ultrasonography, and prostate-specific antigen tests should also be performed.2 Complete surgical excision of the skin and
Conclusions
To reduce the recurrence of EMPD, it is important to treat such patients with complete excision and to confirm that the surgical margin is negative. Other treatment options include topical or systemic chemotherapy and radiotherapy, but these are less effective and result in a high recurrence rate in patients with invasive Paget's disease. However, if the lesion is too large to reconstruct with skin grafts or if the patient cannot tolerate the operation, alternative treatments, such as topical
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Extramammary Paget's disease of scrotum
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Extramammary Paget's disease of the perianal skin: Role of radiotherapy
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Cited by (8)
Advanced Scrotal Extramammary Paget's Disease Treated With Apatinib: A Case Report
2018, Clinical Genitourinary CancerCitation Excerpt :EMPD is commonly divided histopathologically into noninvasive and invasive types.7 Noninvasive EMPD grows slowly and only spreads in the epidermal layer, whereas invasive EMPD is more aggressive and can penetrate into the dermis.7,8 The inguinal lymph nodes are the most common site of metastasis, as in the current case, and the disease can also metastasize to the bones and internal organs.1,2
Interdisciplinary collaboration in a case of scrotal extramammary Paget's disease
2021, Postepy Dermatologii i AlergologiiPaget's disease of scrotum and penis case report of a re-irradiation and review of the literature
2020, Dermatologic TherapyExtramammary Paget’s disease of the perianal region treated successfully with radiotherapy
2015, International Journal of Colorectal DiseaseExtramammary Paget disease of external genitalia: Surgical excision and follow-up experiences with 19 patients
2013, Korean Journal of Urology