Elsevier

Seizure

Volume 14, Issue 8, December 2005, Pages 611-613
Seizure

CASE REPORT
Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy

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Summary

GABA(B) receptor1 (GABABR1) gene is one of the susceptibility genes for temporal lobe epilepsy (TLE). Recently, it is reported that the GABABR1 polymorphism (G1465A) conferred a highly increased susceptibility to TLE. We performed a case-control study to confirm the findings. The study included a total of 112 nonlesional TLE patients and 124 controls of Chinese ancestry. Our study did not show any polymorphism in this locus, and suggested this polymorphism may not be a strong susceptibility factor for TLE among Chinese population.

Keywords

GABABR1 gene
Temporal lobe epilepsy

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1

Present address: Department of Neurology, China–Japan Friendship Hospital, Beijing, PR China.