Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1
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Acknowledgments
This research was supported, in part, by the Ministry of Science and Technology of China (Grant numbers: 2012AA020308, 2009CB918503) and the National Science Foundation of China (Grant numbers: 20873003, 11021463).
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2018, Biotechnology AdvancesCitation Excerpt :Moreover, the structurally related derivative YS121 (Koeberle et al., 2008b, 2010) was recently shown to decrease pancreatic intraepithelial neoplasia lesions and tumor growth in KrasG12D mice that were deficient of natural killer T cells (Janakiram et al., 2017). Other structural series of dual mPGES-1/5-LO inhibitors include non-acidic benzo[g]indole-3-carboxylates (Koeberle et al., 2009b), benzo[d]isothiazole-1,1-dioxides (Shang et al., 2014) and synthetic derivatives of natural products, i.e., myrtucommulones (Wiechmann et al., 2015b), curcuminoids (Koeberle et al., 2014) and benzoquinones (Filosa et al., 2015). Very recently, the 4,5-diaryloxazol-3-carboxylate BRP-187 was described to inhibit FLAP and mPGES-1 (Garscha et al., 2016).