Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1864, Issue 5, Part B, May 2018, Pages 1968-1983
Lipid droplet proteins and metabolic diseases☆
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Abbreviations
LDs
lipid droplets
PLIN1
perilipin
ADRP/PLIN2
adipocyte differentiation related protein
TAG
triacylglycerol
SE
sterol ester
GWS
genome-wide screens
ER
endoplasmic reticulum
FSP27
fat specific protein 27
Rab8a
ras-related protein Rab-8a
GDP
guanosine diphosphate
LPCAT1, 2
lysophosphatidylcholine acyltransferases 1 and 2
PC
phosphatidylcholine
ACSL3
long-chain acyl-coenzyme A synthetase 3
ATGL
adipose triglyceride lipase
HSL
hormone sensitive lipase
CD36
cluster of differentiation 36
FATP
fatty acid transport protein
AGPAT
1-acylglycerol-3-phosphate O-acyltransferase
LIPIN
phosphatidate phosphatase
RBPR
retinol binding protein receptor
CPT
carnitine palmitoyltransferase
ABCA1
ATP binding cassette aubfamily A member 1
ABCG1
ATP binding cassette subfamily G Member 1
SR-BI
scavenger receptor class B member 1
AS160
Akt substrate of 160 kDa
GTP
guanosine triphosphate
CCT1
CTP:phosphocholine cytidylyltransferase
PLIN3
TIP47
PLIN4
S3-12
PLIN5
OXPAT/MLDP/PAT-1
HCV
Hepatitis C Virus
ApoE
Apolipoprotein E
CGI-58
abhydrolase domain containing 5
MLDS
microorganism lipid droplet small
PKA
protein kinase A
CE
cholesteryl ester
acyl-CoA
acyl-coenzyme A
DGAT
acyl-CoA:diacylglycerol acyltransferase
ACAT
acyl-CoA:cholesterol acyltransferase
LART
lecithin:retinol acyltransferase
RE
retinyl ester
GPAT4
glycerol-3-phosphate acyltransferase 4
DAG
diacylglycerol
MAG
monoacylglycerol
MGL
monoacylglycerol lipase
FFA
free fatty acid
FASN
fatty acid synthase
DENV
dengue virus
AUP1
ancient ubiquitous protein 1
CIDE
cell death-inducing DFFA-like effector
IMCL
intramyocellular lipids
FC
free cholesterol
HDL
high density lipoproteins
nCEH
neutral cholesteryl ester hydrolase
CES1
carboxylesterase 1
NCEH1
neutral cholesterol ester hydrolase 1
LDAH
lipid droplet associated hydrolase
LDL
low density lipoprotein
NAFLD
nonalcoholic fatty liver disease
NASH
non-alcoholic steatohapatitis
HCC
hepatocellular carcinoma
PNPLA3
patatin like phospholipase domain containing 3
LIPC/HTGL
hepatic lipase
LYPLAL1
lysophospholipase-like1
17β-HSD13
17β-hydroxysteroid dehydrogenase 13
SCDR9
short-chain dehydrogenase/reductase 9
HSCs
hepatic stellate cells
WAT
white adipose tissue
ADHs
alcohol dehydrogenases
RAs
retinoic acids
RALDHs
retinaldehyde dehydrogenases
NLSD
neutral lipid storage disease
NLSDM
NLSD with severe myopathy
NLSDI
NLSD with ichthyosis
CGL
congenital generalized lipodystrophy
FPL
familial partial lipodystrophy
LPL
lipoprotein lipase
T2D
type 2 diabetes
ROS
reactive oxygen species
CHD
coronary heart disease
AD
Alzheimer's disease
MI
myocardial infarction
PAH
pulmonary arterial hypertension
CMT
Charcot-Marie-Tooth disease
Keywords
Lipid droplets
Ectopic lipid storage
Metabolic diseases
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This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.
© 2017 Published by Elsevier B.V.