Case reportClonal Light Chain Restricted Primary Intrapulmonary Nodular Amyloidosis
Section snippets
Patient 1
This 60-year-old woman presented in the summer of 2003 with a pneumothorax. Radiographic studies at that point in time revealed a right lung mass. Specifically, computed tomography of the chest revealed a 2.3 × 2.7 cm mass involving the lateral segment of the middle lobe as well as two smaller subpleural nodules, more anteriorly in the middle lobe measuring roughly 7 mm in size and 1.1 cm, respectively (Fig 1, Fig 2, Fig 3). A fine needle aspiration was interpreted as representing nonsmall cell
Comment
We have presented two cases of localized intrapulmonary nodular amyloidosis, whereby the pathologic evidence of their categorization was low grade B cell lymphoproliferative disease and more specifically, localized forms of plasma cell dyscrasia. First, light chain restricted plasmacellular infiltrates were observed in both cases, one with cardinal features of B cell neoplasia. Second, both cases had an accompanying small lymphocytic infiltrate composed almost exclusively of B cells in contrast
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Cited by (9)
A rare case of isolated thoracic AL-amyloidoma causing complete atelectasis of the right lung
2023, Respiratory Medicine Case ReportsHematolymphoid neoplasms with a plasma cell phenotype
2020, Seminars in Diagnostic PathologyCitation Excerpt :At the periphery of the nodules usually scant infiltrate of lymphocytes or plasma cells may be seen. In cases associated with a B-cell lymphoproliferative disorder, the B-cell component may be only identified using sensitive clonality studies. 16-18 The differential diagnosis includes pulmonary hyalinizing granuloma and light chain deposition disease, which may show amyloid-like deposition. 19
Isolated pulmonary amyloidomas: Report of 3 cases with histologic and imaging findings
2013, Pathology Research and PracticeCitation Excerpt :Furthermore, the rarity of amyloid stroma in marginal zone lymphomas was stressed [5,6]. Ross et al. published 2 amyloid tumors of the lung without overt lymphoma, but with a kappa light-chain restricted plasma cell infiltrate, confirmed by polymerase chain reaction testing of paraffin-embedded tissue [21]. Ross et al's report and others have shown light chain restriction in plasma cell infiltrates of nodular pulmonary amyloidomas [17,22–26], and have somewhat blurred the previous clear-cut distinction between isolated amyloidoma of the lung and plasmacytoid lymphoma.
Localized Amyloidosis of the Upper Aerodigestive Tract: Complex Analysis of the Cellular Infiltrate and the Amyloid Mass
2019, Analytical Cellular PathologyAmyloidosis of the lung
2017, Archives of Pathology and Laboratory Medicine