ReviewPositive and negative regulation of glucose uptake by hyperosmotic stress
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2022, European Journal of Medicinal ChemistryD-mannitol modulates glucose uptake ex vivo; suppresses intestinal glucose absorption in normal and type 2 diabetic rats
2019, Food BioscienceCitation Excerpt :Other amino acid residues formed hydrophobic interactions, which led to the stabilization of the complex (Fig. 6). Furthermore, a previous study reported that hyperosmolarity increases muscle glucose uptake by modulating AMP-kinase and/or inhibiting the endocytosis of GLUT-4 (Gual, Le Marchand-Brustel, & Tanti, 2003). Thus, the increasing osmolarity of the glucose uptake assay incubation solution (0.45–1.42 Osm/L), caused by the increasing concentration (2.5–20% w/v) of mannitol, may contribute to its dose-dependent glucose uptake effect, perhaps using a GLUT 4-associated mechanism.
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