The Journal of Steroid Biochemistry and Molecular Biology
Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells
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2023, Bioorganic ChemistryCitation Excerpt :After this period, cells were cultured and incubated with testosterone (T) (Sigma-Aldrich Co., Saint Louis, USA), at 1 nM, the natural substrate of aromatase that is converted by this enzyme into estrogen, which induces cell proliferation. Thus, T was used as a cell proliferation induction agent, to better mimic the microenvironment of ER+ breast tumors [19,40]. After T, cells were also incubated with each compound.
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2023, Journal of Herbal MedicineCitation Excerpt :Chromatographic and detection specifications were already reported elsewhere (El-Abid et al., 2019). MCF-7aro is a human ER+ breast cancer cell line that overexpresses aromatase, which is a good in vitro cell model to study this type of cancer (Sun et al., 1997; Zhou et al., 1990) and was kindly provided by Professor Shiuan Chen (Beckman Research Institute, City of Hope, Duarte, CA, USA). These cells grew with Eagles’ minimum essential medium (MEM) supplemented with 1% penicillin–streptomycin–amphotericin B, Earle’s salts and 1 mmol/L sodium pyruvate, 100 µg/mL G418, and 10% of heat-inactivated fetal bovine serum (FBS) (Gibco Invitrogen Co., Paisley, Scotland, UK).
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