Short communicationEffect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus
Section snippets
Acknowledgements
This work was supported by a research grant for cardiovascular diseases from the Japanese Ministry of Health and Welfare and was in part supported by Health Science Research Grants by the Ministry of Health and Welfare of Japan. We also wish to express our thanks to Dr. H. Naritomi (National Cardiovascular Center, Osaka, Japan) who gave us supports for experimental preparations in this study and Ms. M. Shimomura and R. Manabe for their secretarial assistance.
References (20)
- Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. and Lipton, S.A., Apoptosis and necrosis: Two distinct events...
- Choi, D.W., Calcium: still center-stage in hypoxic-ischemic neuronal death, Trends Neurosci., 18 (1995)...
- Cohen, J.J. and Duke, R.C., Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to...
- Frederickson, C.J., Hernandez, M.D. and McGinty, J.F., Translocation of zinc may contribute to seizure-induced death of...
- Gavrieli, Y., Sherman, Y. and Bensasson, S.A., Identification of programmed cell death in situ via specific labeling of...
- Kitagawa, K., Matsumoto, M., Oda, T., Niinobe, M., Hata, R., Handa, N., Fukunaga, R., Isaka, Y., Kimura, K., Maeda, H.,...
- Koh, J., Suh, S.W., Gwag, B.J., He, Y.Y., Hsu, C.Y. and Choi, D.W., The role of zinc in selective neuronal death after...
- Li, H. and Buchan, A.M., Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia...
- Linnik, M., Zobrist, R.H. and Hatfield, M.D., Evidence supporting a role for programmed cell death in focal cerebral...
- MacManus, J.P., Buchan, A.M., Hill, I.E., Rasquinha, I. and Preston, E., Global ischemia can cause DNA fragmentation...
Cited by (67)
The critical role of the zinc transporter Zip2 (SLC39A2) in ischemia/reperfusion injury in mouse hearts
2019, Journal of Molecular and Cellular CardiologyCitation Excerpt :Zinc is essential for the structure and function of many proteins [1] and has been demonstrated to be cytoprotective [2,3].
The effect of zinc acexamate on oxidative stress, inflammation and mitochondria induced apoptosis in rat model of renal warm ischemia
2018, Biomedicine and PharmacotherapyCitation Excerpt :Moreover, it has been shown that apoptosis was increased in different Zn deprivation models [53,54]. Indeed, Zn supply prevented apoptosis following transient forebrain ischemia [55] and Zn chelation increased caspase-3 activity [56]. In our study, the significant decrease of the pro-apoptotic protein caspase-9 confirmed the protective role of ZAC at 10 mg/kg against apoptosis.
Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion
2015, Journal of Inorganic BiochemistryCitation Excerpt :The influence of zinc on apoptosis is a well known phenomenon [30]. In both in vitro and in vivo models, zinc supplementation prevents apoptosis induced by a variety of agents [31,32]. Moreover, cells grown under conditions of zinc deficiency will undergo spontaneous apoptosis [33,34].
Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells
2015, BloodCitation Excerpt :One key physiological regulator that maintains the executioner caspase in an inactive procaspase configuration is its inhibition by labile intracellular zinc.4 After the first demonstration that addition of zinc ion specifically inhibited caspase-3 cleavage activity and caspase-3–mediated apoptosis,5 a series of reports showed that addition of zinc increased cytoprotection6,7 and deprivation of zinc ion induced apoptosis.8-10 These findings provided an impetus to create small molecules to chelate the intracellular zinc to activate caspases.11
The role of zinc in immunity and inflammation
2013, Diet, Immunity and InflammationComparison of uptake and neuroprotective potential of seven zinc-salts
2010, Neurochemistry International