Session 1Gluco-lipotoxicity of the pancreatic beta cell
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The clinical and metabolic characteristics of young-onset ketosis-prone type 2 diabetes in China
2015, Endocrine PracticeCitation Excerpt :Our data support the hypothesis that a disturbance in glucose metabolism might play an important role in the pathogenesis of KPD. Some studies have proven that β- and α-cell dysfunction both contribute to the pathophysiology of KPD (31), but the role of lipotoxicity in the β-cell failure observed in KPD patients is controversial (32–34). In our study, the lipid profile was more severely disturbed in the KPD group than in the type 1 diabetes or type 2 diabetes groups.
New avenues for the pharmacological management of type 2 diabetes: An update
2012, Annales d'EndocrinologieCitation Excerpt :Similar to the action of incretins, circulating free fatty acids (FFA) play a critical role on pancreatic β-cell physiology, especially on insulin secretion [66,67]. The chronic increase of FFA a phenomenon called lipotoxicity, has been well described to be a major player in the pathophysiology of T2DM, at least by inhibiting insulin secretion and leading to β-cell apoptosis [68]. Conversely, circulating FFA are also able to amplify early insulin secretion, as physiologically observed during food intake [69].
The metabolic syndrome. Beyond the insulin resistance syndrome
2006, Pharmacological ResearchThe first series of cases of ketosisprone type 2 diabetes (Flatbush diabetes) in Brazilian adults
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