Original articleClinical endoscopyHyperplastic polyposis syndrome: a pilot study for the differentiation of polyps by using high-resolution endoscopy, autofluorescence imaging, and narrow-band imaging
Section snippets
Study population
This study was conducted at the Academic Medical Center Amsterdam and was approved by the local medical ethics committee. Consecutive patients with HPS were invited to participate when fulfilling the criteria for HPS in accordance with the World Health Organization: (1) at least 5 histologically confirmed HPs proximal to the sigmoid colon, of which 2 are greater than 10 mm in diameter, or (2) more than 30 HPs distributed throughout the colon.35 Patients younger than 18 years of age or patients
Results
From January 2005 to July 2006, 7 patients (5 men, 2 women) who met the criteria for HPS underwent colonoscopy with ETMI. The median age of all patients was 55.8 years (range 54-71 years). At colonoscopy, all patients had good to moderate bowel preparation. A total of 66 polyps (19 HPs, 32 SSAs, and 15 tubular adenomas) were detected as well as 10 additional lesions displaying normal mucosa on histology (excluded from the analysis). Macroscopic polyp characteristics are summarized in Table 1.
Discussion
In this study, SSAs were significantly larger and more often proximally located than HPs, but the latter finding has its nominal significance removed by Bonferroni correction for multiple testing of data. This is in concordance with recent comparative studies in which sporadic SSAs were also found to be larger than sporadic HPs and preferentially located in the right colon, whereas HPs were more often found distally.12, 18, 42 Interestingly, in our study, the combination of a size of 3 mm or
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DISCLOSURE: The following authors disclosed financial relationships relevant to this publication: F.J.C. van den Broek is supported by an unrestricted educational grant from Olympus Medical Systems, Hamburg, Germany. P. Fockens has received a research grant from Olympus Inc, Tokyo, Japan. Olympus Medical Systems provided the Department of Gastroenterology at our institution with endoscopic equipment for this study. All other authors disclosed no financial relationships relevant to this publication.
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