Short reportIntra-rectal injection of tumour cells: a novel animal model of rectal cancer☆
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Cited by (35)
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy
2021, Seminars in Cancer BiologyCitation Excerpt :Using orthotopic tumor models could be a promising strategy to evaluate the efficacy of anti-tumor treatments [149]. Kashtan and colleagues showed that the intrarectal injection of cell lines is more accurate than other models for evaluating colorectal cancers in human [150]. In 2014, Karla et al. showed a significant variation across the tumor cell-derived xenografts and tumor cell explants in terms of accumulation of liposomal irinotecan.
From mice to men: Murine models of colorectal cancer for use in translational research
2016, Critical Reviews in Oncology/HematologyCitation Excerpt :Transanal injection of tumour cells has also been utilised as a model of rectal cancer, avoiding the need for laparotomy. This method again requires general anaesthesia, followed by anal dilatation with blunt forceps and the injection of a suspension of cells into the rectal mucosa (Kashtan et al., 1992; Donigan et al., 2009). Metastatic rates vary depending on the cell line, site of implantation and murine strain.
Intestinal delivery of non-viral gene therapeutics: Physiological barriers and preclinical models
2011, Drug Discovery TodayCitation Excerpt :This can be achieved by genetic or chemical methods. Similar to the induction of subcutaneous tumour growth described above, cancer cells can also be injected into the large intestine, inducing local tumour growth as well as metastases in other tissues [115]. The use of the carcinogen azoxymethane (AOM) or its precursor 1,2-dimethylhdrazine (DMH) is among the most commonly used chemical approaches, with AOM being used more routinely owing to its higher potency [116,117].
Suppression of colon cancer metastasis by aes through inhibition of notch signaling
2011, Cancer CellCitation Excerpt :To identify genes responsible for metastasis suppression, we first prepared a syngeneic and orthotopic transplantation model of colon cancer metastasis in the mouse. When injected into the rectal smooth muscle layer, Colon26 cells can metastasize to the liver, lungs, and lymph nodes in the Balb/c hosts at different efficiencies (Corbett et al., 1975; Kashtan et al., 1992; Tsutsumi et al., 2001) (see Figures S1A–S1F available online). As a preliminary screening, we compared gene expression profiles between the primary tumors and their liver metastases using cDNA microarrays.
Novel Murine Model for Colon Cancer: Non-Operative Trans-Anal Rectal Injection
2009, Journal of Surgical ResearchCitation Excerpt :In this article, we describe a trans-anal injection of colon cancer cells in BALB/c mice. The method is similar to the intra-rectal injection [8] but is performed with a few modifications. This modified orthotopic murine model that does not require abdominal surgery for injection of colon cancer cells makes it a reliable and clinical relevant technique to study the inflammation and immune response subsequent to cecal resection.
Animal Models for Liver Metastases of Colorectal Cancer: Research Review of Preclinical Studies in Rodents
2009, Journal of Surgical Research
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Presented in part at the American Association for Cancer Research Houston, May, 1991.